| Project/Area Number |
15K08009
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Natural medicines
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| Research Institution | Kindai University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MORIKAWA Toshio 近畿大学, 薬学総合研究所, 教授 (10340449)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 糖尿病 / インスリン / コウズク / phenylpropanoid / センキュウ / phthalide / Carapa guianensis / limonoid / 肥満 / 脂肪肝 / 高インスリン血症 / ローズヒップ / アンディローバ / 耐糖能 / 肥満症 / インスリン抵抗性 |
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| Outline of Final Research Achievements |
The aim of this study is to find the compounds that improve hyperinsulinemia from medicinal foods. In results of this study, we found phenylpropanoids from fruit of Alpinia galanga, phthalides from rhizomes of Cnidium officinale, and limonoids from seed oil of Carapa guianensis as bioactive constituents. Reduction of triglyceride contents in HepG2 cells was observed by addition of these compounds in culture medium. Furthermore, only three times administration of phenylpropanoids, 1'S1-acetoxychavicol acetate and 1'S1-acetoxyeugenol acetate isolated from A. galanga, ameliorated glucose tolerance in mice. Additionaly, triglyceride contents in liver was reduced by the administration in mice.
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