Discovery of new drug seeds for psychiatric disorders targeting DNA methylation
| Project/Area Number |
15K08011
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Natural medicines
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| Research Institution | Setsunan University |
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Principal Investigator |
INATOMI Yuka 摂南大学, 薬学部, 助教 (00258089)
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| Co-Investigator(Kenkyū-buntansha) |
荒木 良太 摂南大学, 薬学部, 助教 (90710682)
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| Project Period (FY) |
2015-10-21 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | DNAメチル化 / 生理活性物質 / 天然物化学 / エピジェネティクス |
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| Outline of Final Research Achievements |
Several studies have suggested that DNA methylation in the promoter regions of Bdnf gene is involved in the development of mood and psychiatric disorders such as depression and schizophrenia. In this study, we established the convenient assay system for evaluation of DNA methylation levels in the bdnf promoter region, by the incorporation of the reporter construct into the genome of Neuro2A cells. The assay system may be a useful screening tool for drug candidates which have DNA demethylation activities.
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Report
(4 results)
Research Products
(2 results)
