Mechanism of lentztrehalose-induced autophagy; its application for the treatment of neurodegenerative diseases
Project/Area Number |
15K08013
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Natural medicines
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Research Institution | Microbial Chemistry Research Foundation |
Principal Investigator |
WADA Shun-ichi 公益財団法人微生物化学研究会, 微生物化学研究所, 研究員 (40450233)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | レンツトレハロース / トレハロース / 神経変性疾患 / アルツハイマー病 / オートファジー |
Outline of Final Research Achievements |
Dozens of new trehalose-type autophagy inducers were discovered or synthesized. Among them, TRH-X was estimated as mass-producible and suitable as the material to synthesize further derivative compounds. Some of the TRH-X derivatives showed higher autophagy inducing activities than trehalose and other analogues. They would be the promising drug candidates for the treatment of neurodegenerative diseases to dissolve the aggregation of abnormal proteins in the neuronal cells. The curative effect of trehalose in Alzheimer’s disease was evaluated using a model mouse. Trehalose administrated mice in the early stage of the disease showed significantly better recognitive function and reduced amyloid plaque. The development and application of the new trehalose analogue compound for the treatment of Alzheimer’s disease are expected.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Structures and biological activities of novel 4’-acetylated analogs of chrysomycins A and B.2017
Author(s)
Wada, S., Sawa, R., Iwanami, F., Nsgayoshi, M., Kubota, Y., Iijima, K., Hayashi, C., Shibuya, Y., Hatano, M., Igarashi, M., Kawada, M.
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Journal Title
J. Antibiot.
Volume: 70
Issue: 11
Pages: 1078-1082
DOI
Related Report
Peer Reviewed
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[Journal Article] ATP Depletion Assay Led to the Isolation of New 36-Membered Polyol Macrolides Deplelides A and B from Streptomyces sp. MM581-NF152017
Author(s)
Toshifumi Takeuchi , Masaki Hatano, Maya Umekita, Chigusa Hayashi, Shun-ichi Wada, Miho Nagayoshi, Ryuichi Sawa, Yumiko Kubota, Manabu Kawada, Masayuki Igarashi, Masakatsu Shibasaki
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Journal Title
Organic Letters
Volume: 19
Issue: 16
Pages: 4207-7210
DOI
Related Report
Peer Reviewed
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[Journal Article] Stability and Bioavailability of Lentztrehaloses A, B, and C as Replacements for Trehalose.2016
Author(s)
Wada S, Sawa R, Ohba S, Hayashi C, Umekita M, Shibuya Y, Iijima K, Iwanami F, Igarashi M.
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Journal Title
J Agric Food Chem.
Volume: 64
Issue: 38
Pages: 7121-7126
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Lentzea属放線菌由来trehalose類縁体lentztrehalose類の構造と生物活性2015
Author(s)
和田 俊一, 澤 竜一, 大庭 俊一, 染野 哲也, 久保田 由美子, 波多野 和樹, 梅北 まや, 張 明, 渡辺 匠, 林 千草, 川田 学, 五十嵐 雅之, 柴﨑 正勝
Organizer
第30回 日本放線菌学会大会
Place of Presentation
富山国際会議場 (富山)
Year and Date
2015-09-08
Related Report
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