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Structure-Activity Relationship and Mechanistic Studies on Sodium 4-phenylbutyrate and its derivatives

Research Project

Project/Area Number 15K08014
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Drug development chemistry
Research InstitutionAsahikawa Medical College

Principal Investigator

OKUDA Katsuhiro  旭川医科大学, 医学部, 助教 (00389115)

Co-Investigator(Kenkyū-buntansha) 佐能 正剛  広島大学, 医歯薬保健学研究科(薬), 助教 (00552267)
太田 茂  広島大学, 医歯薬保健学研究科(薬), 教授 (60160503)
酒井 規雄  広島大学, 医歯薬保健学研究科(医), 教授 (70263407)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords化学シャペロン / 構造活性相関
Outline of Final Research Achievements

4PBA was valued its properties by 5 kind of assays. We have determined each criteria to compare the properties with those of other derivatives. Forty 4PBA derivatives were designed then purchased or synthesized as its sodium salt. The derivatives were applied for the assays. Coefficient of correlation values were calculated between some parameters and mRNA expression amount. Four and three genes correlated highly with chaperonic activity or HDAC inhibitory activity, respectively.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2016 2015

All Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] 化学シャペロンSodium 4-phenylbutyrate の構造活性相関研究(2)2016

    • Author(s)
      奥田 勝博, 佐々木 律枝, 保科 千里, 酒井 規雄, 太田 茂, 清水 惠子
    • Organizer
      日本薬学会 第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-29
    • Related Report
      2015 Research-status Report
  • [Presentation] Structure-Activity Relationship and Mechanistic Studies on Sodium 4-phenylbutyrate and its derivatives2015

    • Author(s)
      Katsuhiro Okuda, Ritsue Sasaki, Chisato Hoshina, Norio Sakai, Shigeru Ohta, Keiko Shimizu
    • Organizer
      10th AFMC International Medicinal Chemistry Symposium
    • Place of Presentation
      チェジュ、韓国
    • Year and Date
      2015-10-20
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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