Application of the multi-template approach for the development of polypharmacological agents
| Project/Area Number |
15K08015
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Yachide Tomomi 東京大学, 分子細胞生物学研究所, 講師 (20401284)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | エピジェネティクス / 構造展開 / 構造活性相関 / ポリファーマコロジー / ブロモドメイン / 多重薬理 / HDAC / 医薬品探索 / 翻訳後修飾 / myc / BETファミリータンパク質 / サリドマイド |
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| Outline of Final Research Achievements |
Polypharmacology has been receiving increasing attention as a novel strategy in drug development. In contrast to the conventional one-drug/one-target philosophy, polypharmacology aims to develop drugs with multiple related targets in order to obtain more robust effects on diseases involving dysfunction of complex biological networks, such as cancers. Based on the idea that polypharmacological agents with multiple targets would have a more robust action, we applied multi-template approach, which we have proposed to develop compounds with diverse biological activities, for the development of polypharmacological agents, and evaluated their biological actions. These results suggest that polypharmacology may be an effective strategy for the treatment of cancers.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Effects of alkyl side chains and terminal hydrophilicity on vitamin D receptor (VDR) agonistic activity based on the diphenylpentane skeleton2015
Author(s)
Takashi Misawa, Momoko Yorioka, Yosuke Demizu, Tomomi Noguchi-Yachide, Nobumichi Ohoka, Megumi Kurashima-Kinoshita, Hitomi Motoyoshi, Hisao Nojiri, Atsushi Kittaka, Makoto Makishima, Mikihiko Naito, Masaaki Kurihara
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Journal Title
Bioorg. Med. Chem. Lett.
Volume: 25
Issue: 22
Pages: 5362-5366
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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