| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
Polypharmacology has been receiving increasing attention as a novel strategy in drug development. In contrast to the conventional one-drug/one-target philosophy, polypharmacology aims to develop drugs with multiple related targets in order to obtain more robust effects on diseases involving dysfunction of complex biological networks, such as cancers. Based on the idea that polypharmacological agents with multiple targets would have a more robust action, we applied multi-template approach, which we have proposed to develop compounds with diverse biological activities, for the development of polypharmacological agents, and evaluated their biological actions. These results suggest that polypharmacology may be an effective strategy for the treatment of cancers.
|
