| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
To develop potent vitamin D receptor ligand which have no vitamin D skeleton and to investigate structure and activity relationships of lithocolic acid derivateves, I designed, synthesized and evaluated biological activity of novel lithocholic acid derivateves. I synthesized several lithocholic acid derivatives which have hydoxyl group containing alkyl group at carbon three on steroid skeleton. The vitamin D receptor activity of synthesized compounds were evaluated by differentiation-inducing activity in HL-60 human promyelocytic leukemia cell line. All of the compounds have higher activity than known lithocholic acid derivatives. The most potent compound have activity as well as 1,25-dihydroxyvitamin D3. These compounds have enough activities to use clinical application.
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