Development of novel functional molecules that selectively functions under disease-specific microenvironment
| Project/Area Number |
15K08019
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Drug development chemistry
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
HIRANO Tomoya 東京医科歯科大学, 生体材料工学研究所, 准教授 (20396980)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 有機化学 / 分析化学 / 蛍光 / pH / 粘性 / 天然物 / 薬学 / 分子イメージング / バイオイメージング / がん / 光分解性保護基 |
|---|
| Outline of Final Research Achievements |
Disease-specific changes of microenvironment could be utilized for diagnosis and drug delivery system. In this research, we have developed various fluorescent sensors for such change. For example, sensors for a specific range of pH, which show “OFF-ON-OFF” type of change and enable detailed analysis of physiological functions. And fluorescent sensors for viscosity change have also been developed. We focused on natural compounds as the source of such molecules, and fluorescent natural compounds, Amarastelline A and Nigakinone, were identified. Based on them, fluorescent compounds with unique and useful functions were also obtained. In addition, the function as a sensor was converted to that as a photoremovable protecting group. By using similar scaffold, we have developed protecting group, which could be photo-removed under a specific range of pH.
|
Report
(4 results)
Research Products
(61 results)
-
-
-
[Journal Article] Sucuipiranins A-L, Furanocassane Diterpenoids from the Seeds of Bowdichia virgilioides,2017
Author(s)
Endo, Y.; Kasahara, T.; Harada, K.; Kubo, M.; Etoh, T.; Ishibashi, M.; Ishiyama, A.; Iwatsuki, M.; Otoguro, K.; Õmura, S.; Akisue, G.; Hirano, T.; Kagechika, H.; Fukuyama, Y.; Ohsaki, A.
-
Journal Title
J. Nat. Prod.
Volume: 80
Issue: 12
Pages: 3120-3127
DOI
Related Report
Peer Reviewed / Int'l Joint Research
-
-
-
-
-
-
-
[Journal Article] Identification of cyproheptadine as an inhibitor of SET domain containing lysine methyltransferase 7/9 (Set7/9) that regulates estrogen-dependent transcription.2016
Author(s)
Takemoto Y, Ito A, Niwa H, Okamura M, Fujiwara T, Hirano T, Handa N, Umehara T, Sonoda T, Ogawa K, Tariq M, Nishino N, Dan S, Kagechika H, Yamori T, Yokoyama S, Yoshida M.
-
Journal Title
J. Med. Chem.
Volume: 59
Issue: 8
Pages: 3650-3660
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
[Journal Article] Design and synthesis of 4-benzyl-1-(2H)-phthalazinone derivatives as novel androgen receptor antagonists2015
Author(s)
Kazumi Inoue, Ko Urushibara, Misae Kanai, Kei Yura, Shinya Fujii, Mari Ishigami-Yuasa, Yuichi Hashimoto, Shuichi Mori, Emiko Kawachi, Mio Matsumura, Tomoya Hirano, Hiroyuki Kagechika, Aya Tanatani
-
Journal Title
European Journal of Medicinal Chemistry
Volume: 102
Pages: 310-319
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] ヒストンメチル化酵素阻害剤の開発2015
Author(s)
平野道丈, 平野智也, 藤原敬士, 大平香澄, 伊藤昭博, 吉田稔, 影近弘之
Organizer
第33回メディシナルケミストリーシンポジウム
Place of Presentation
幕張国際研修センター（幕張）
Year and Date
2015-11-26
Related Report
-
-
-
-
-
-
-
-
-
