| Project/Area Number |
15K08023
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Shinshu University |
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Principal Investigator |
WADA YUKO 信州大学, 学術研究院医学系(医学部附属病院), 講師 (30419410)
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| Co-Investigator(Kenkyū-buntansha) |
瀬戸 達一郎 信州大学, 学術研究院医学系, 准教授 (70362118)
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| Research Collaborator |
TANAKA Yuki 信州大学, 医学部, 技能補佐員
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 血管新生療法 |
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| Outline of Final Research Achievements |
In this study we showed that B.Longum (BL), an anaerobic bacterium, accumulates specifically in the myocardial infarction site by intravenous administration, and are promptly removed from the non-ischemic site. This finding indicates that BL may be useful vector for ischemic heart disease.
We developed the new therapeutic angiogenesis drug for ischemic heart disease, FGF-BL incorporating bFGF gene into this vector, and performed a therapeutic experiment on guinea pig myocardial infarction model using FGF-BL. We confirmed that FGF-BL was specifically delivered to myocardial infarction site, but this agent did not show improvement effect for LV function.
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