Development of Nucleic Acid Medicines Based on Synthetic Study of Novel Nucleoside Derivatives
| Project/Area Number |
15K08028
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Drug development chemistry
|
|---|
| Research Institution | Tohoku Medical and Pharmaceutical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | ヌクレオシド / オリゴヌクレオチド / 抗HIV薬 / グリコシル化反応 / アルドール反応 / グリコシル化 / ルイス酸 / 環化反応 |
|---|
| Outline of Final Research Achievements |
To develop nucleic acid medicines resistant to nuclease with good duplex stability, three new nucleoside derivatives to be used as a synthetic unit for oligonucleotides were designed and synthesized.
|
Report
(4 results)
Research Products
(15 results)
