Development of Inhibitors of Human Parainfluenza Virus for Prevention of Multi-infectious Diseases
| Project/Area Number |
15K08037
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Hiroshima International University |
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Principal Investigator |
Ikeda kiyoshi 広島国際大学, 薬学部, 教授 (40168125)
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI TAKASHI 静岡県立大学, 薬学部, 教授 (20240947)
TAKAHASHI TADANOBU 静岡県立大学, 薬学部, 准教授 (20405145)
TOKIWA HIROAKI 立教大学, 理学部, 教授 (10221433)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | シアリダーゼ阻害剤 / 蛍光イメージングプローブ / パラインフルエンザウイルス / シアル酸 / ヒトパラインフルエンザウイルス (hPIV) / 病原性ウイルス / HN糖蛋白質シアリダーゼ / in silico創薬 / シアリダーゼ / HN糖蛋白質 / 顔料系色素蛍光剤 / ハイリスク群患者 / 多重感染 / ハイブリッド型 |
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| Outline of Final Research Achievements |
Human parainfluenza virus type 1 (hPIV-1) is a serious pathogen causing upper and lower respiratory disease in infants and young children; however, there are no known effective inhibitors of hPIV-1 infection. We developed a novel fluorescent sialidase substrate, BTP3-Neu5Ac derivatives, which have imaging of sialidase activity by a highly sensitive fluorescent histochemical method. 2. For the synthesis of the potent and selective inhibitors of human parainfluenza virus, we synthesized compounds having guanigyl group and several acyl functions at C-4 position of sialic acid. Compound bearing guanigyl group showed no effect against hPIV, But, compoundd bearing Ac group showed inhibitory activity against hPIV.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Rapid regulation of sialidase activity in response to neural activity and sialic acid removal during memory processing in rat hippocampus.2017
Author(s)
Akira Minami, Yuko Meguro, Sayaka Ishibashi, Ami Ishii, Mako Shiratori, Saki Sai, Yuuki Horii, Hirotaka Shimizu, Hokuto Fukumoto, Sumika Shimba, Risa Taguchi, Tadanobu Takahashi, Tadamune Otsubo, Kiyoshi Ikeda and Takashi Suzuki.
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Journal Title
J. Biol. Chem.
Volume: 292
Issue: 14
Pages: 5645-5654
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Substrate Specificity of Equine and Human Influenza A Virus Sialidase to Molecular Species of Sialic Acid2016
Author(s)
Tadanobu Takahashi, Saori Unuma, Sawako Kawagishi, Yuuki Kurebayashi, Maiko Takano, Hiroki Yoshino, Akira Minami, Takashi Yamanaka, Tadamune Otsubo, Kiyoshi Ikeda, Takashi Suzuki.
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Journal Title
Biological and Pharmaceutical Bulletin
Volume: 39
Issue: 10
Pages: 1728-1733
DOI
NAID
ISSN
0918-6158, 1347-5215
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Rapid fluorescent detection assay for human parainfluenza viruses2015
Author(s)
Tadanobu Takahashi, Maiko Takano, Yuuki Kurebayashi, Takashi Agarikuchi, Chihiro Suzuki, Keijo Fukushima, Shunsaku Takahashi, Tadamune Otsubo, Kiyoshi Ikeda, Akira Minami, Takashi Suzuki
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Journal Title
Biol. Pharm. Bull
Volume: 38
Pages: 1214-1219
NAID
Related Report
Peer Reviewed
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