| Project/Area Number |
15K08037
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Hiroshima International University |
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Principal Investigator |
Ikeda kiyoshi 広島国際大学, 薬学部, 教授 (40168125)
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI TAKASHI 静岡県立大学, 薬学部, 教授 (20240947)
TAKAHASHI TADANOBU 静岡県立大学, 薬学部, 准教授 (20405145)
TOKIWA HIROAKI 立教大学, 理学部, 教授 (10221433)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | シアリダーゼ阻害剤 / 蛍光イメージングプローブ / パラインフルエンザウイルス / シアル酸 / ヒトパラインフルエンザウイルス (hPIV) / 病原性ウイルス / HN糖蛋白質シアリダーゼ / in silico創薬 / シアリダーゼ / HN糖蛋白質 / 顔料系色素蛍光剤 / ハイリスク群患者 / 多重感染 / ハイブリッド型 |
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| Outline of Final Research Achievements |
Human parainfluenza virus type 1 (hPIV-1) is a serious pathogen causing upper and lower respiratory disease in infants and young children; however, there are no known effective inhibitors of hPIV-1 infection. We developed a novel fluorescent sialidase substrate, BTP3-Neu5Ac derivatives, which have imaging of sialidase activity by a highly sensitive fluorescent histochemical method. 2. For the synthesis of the potent and selective inhibitors of human parainfluenza virus, we synthesized compounds having guanigyl group and several acyl functions at C-4 position of sialic acid. Compound bearing guanigyl group showed no effect against hPIV, But, compoundd bearing Ac group showed inhibitory activity against hPIV.
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