• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Role of reactive sulfur species and ER stress response in protection against cadmium toxicity

Research Project

Project/Area Number 15K08042
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Environmental and hygienic pharmacy
Research InstitutionUniversity of Tsukuba

Principal Investigator

Shinkai Yasuhiro  筑波大学, 医学医療系, 助教 (10454240)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsカドミウム / 活性イオウ分子 / 小胞体ストレス応答 / イオウ付加体 / ポリスルフィド / 化学防御 / シスタチオニンγリアーゼ / シスタチオニンβシンターゼ
Outline of Final Research Achievements

Cadmium has electrophilic property to modify cysteine residues in cellular proteins, resulting in its dysfunction and cytotoxicity. In this study, role of reactive sulfur species such as persulfides/polysulfides and ER stress response in protection against cadmium toxicity was examined. We found that cadmium induces enzymes associated with the production of reactive sulfur species. Also, reactive sulfur species were found to be protective against cadmium toxicity via formation of sulfur adducts of cadmium.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (24 results)

All 2018 2017 2016 2015 Other

All Journal Article (8 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 8 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (14 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results) Remarks (2 results)

  • [Journal Article] Biglycan Intensifies ALK5-Smad2/3 Signaling by TGF-β1 and Downregulates Syndecan-4 in Cultured Vascular Endothelial Cells2017

    • Author(s)
      Hara Takato、Yoshida Eiko、Shinkai Yasuhiro、Yamamoto Chika、Fujiwara Yasuyuki、Kumagai Yoshito、Kaji Toshiyuki
    • Journal Title

      Journal of Cellular Biochemistry

      Volume: 118 Issue: 5 Pages: 1087-1096

    • DOI

      10.1002/jcb.25721

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 1,4-Naphthoquinone activates the HSP90/HSF1 pathway through the S-arylation of HSP90 in A431 cells: Negative regulation of the redox signal transduction pathway by persulfides/polysulfides2017

    • Author(s)
      Abiko Y, Sha L, Shinkai Y, Unoki T, Luong NC, Tsuchiya Y, Watanabe Y, Hirose R, Akaike T, Kumagai Y.
    • Journal Title

      Free Radic Biol Med

      Volume: 104 Pages: 118-128

    • DOI

      10.1016/j.freeradbiomed.2016.12.047

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Polysulfide Na2S4 regulates the activation of PTEN/Akt/CREB signaling and cytotoxicity mediated by 1,4-naphthoquinone through formation of sulfur adducts2017

    • Author(s)
      Abiko Yumi、Shinkai Yasuhiro、Unoki Takamitsu、Hirose Reiko、Uehara Takashi、Kumagai Yoshito
    • Journal Title

      Scientific Report

      Volume: 7 Issue: 1 Pages: 4814-4814

    • DOI

      10.1038/s41598-017-04590-z

    • NAID

      120007128910

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Capture of Cadmium by Reactive Polysulfides Attenuates Cadmium-Induced Adaptive Responses and Hepatotoxicity2017

    • Author(s)
      Akiyama Masahiro、Shinkai Yasuhiro、Unoki Takamitsu、Shim Ilseob、Ishii Isao、Kumagai Yoshito
    • Journal Title

      Chem Res Toxicol

      Volume: 30 Issue: 12 Pages: 2209-2217

    • DOI

      10.1021/acs.chemrestox.7b00278

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Cadmium-mediated activation of the HSP90/HSF1 pathway regulated by reactive persulfides/polysulfides.2017

    • Author(s)
      Shinaki Y,Masuda A, Akiyama M, Xian M, Kumagai Y.
    • Journal Title

      Toxicolgical Sciences

      Volume: 156 Pages: 412-421

    • DOI

      10.1093/toxsci/kfw268

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] NADPH-cytochrome P450 reductase-mediated denitration reaction of 2,4,6-trinitrotoluene to yield nitrite in mammals2016

    • Author(s)
      Shinkai Y, Nishihara Y, Amamiya M, Wakayama T, Li S, Kikuch T, Nakai Y, Shimojo N, Kumagai Y
    • Journal Title

      Free Radical Biology and Medicine

      Volume: 91 Pages: 178-187

    • DOI

      10.1016/j.freeradbiomed.2015.09.011

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Participation of metabolic activation of 2,4,6-trinitrotoluene to 4-hydroxylamino-2,6-dinitrotoluene in hematotoxicity2015

    • Author(s)
      Shinkai Y, Li S, Kikuchi T, Kumagai Y
    • Journal Title

      The Journal of Toxicological Sciences

      Volume: 40 Issue: 5 Pages: 597-604

    • DOI

      10.2131/jts.40.597

    • NAID

      130005098386

    • ISSN
      0388-1350, 1880-3989
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Health survey of workers in a 2,4,6-trinitrotoluene explosives factory in Fuxin, China2015

    • Author(s)
      Shinkai Y, Li S, Kikuchi T, Shimojo N, Kumagai Y
    • Journal Title

      Fundamental Toxicological Sciences

      Volume: 2 Issue: 4 Pages: 171-175

    • DOI

      10.2131/fts.2.171

    • NAID

      130005100438

    • ISSN
      2189-115X
    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Cadmium-Mediated Activation of the HSP90/ HSF1 Pathway Regulated by Reactive Persulfides and Polysulfides2018

    • Author(s)
      Shinkai Y, Masuda A, Akiyama M, Xian M, Kumagai Y
    • Organizer
      Society of Toxicology 57th Annual Meeting
    • Related Report
      2017 Annual Research Report
  • [Presentation] カドミウムの毒性を制御する活性イオウ分子2018

    • Author(s)
      新開泰弘
    • Organizer
      日本薬学会 第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 活性イオウ分子を介したカドミウムの肝毒性の防御機構2017

    • Author(s)
      新開泰弘、秋山雅博、鵜木隆光、石井功、熊谷嘉人
    • Organizer
      第70回日本酸化ストレス学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 活性イオウ分子によるカドミウムの不活性化を介した肝毒性および生体応答の制御2017

    • Author(s)
      新開泰弘、秋山雅博、鵜木隆光、石井功、熊谷嘉人
    • Organizer
      第44回日本毒性学会学術年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 活性イオウ分子はカドミウムの不活性化を介して生体応答および肝毒性の惹起を負に制御する2017

    • Author(s)
      新開泰弘、秋山雅博、鵜木隆光、石井功、熊谷嘉人
    • Organizer
      フォーラム2017:衛生薬学・環境トキシコロジー
    • Related Report
      2017 Annual Research Report
  • [Presentation] カドミウムによるレドックスシグナル伝達経路の活性化とその制御系2016

    • Author(s)
      新開泰弘、熊谷嘉人
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 活性イオウ分子によるカドミウムの毒性防御の分子機構2016

    • Author(s)
      新開泰弘、熊谷嘉人
    • Organizer
      第69回日本酸化ストレス学会学術集会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-08-30
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] カドミウムの肝毒性に対する活性イオウ分子の防御的役割2016

    • Author(s)
      新開泰弘、秋山雅博、鵜木隆光、熊谷嘉人
    • Organizer
      オルガネラ研究会2016
    • Place of Presentation
      生理学研究所(愛知県岡崎市)
    • Year and Date
      2016-07-28
    • Related Report
      2016 Research-status Report
  • [Presentation] カドミウムによるHSP90の化学修飾を介した転写因子HSF1の活性化とその防御的役割2016

    • Author(s)
      新開泰弘、増田章、熊谷嘉人
    • Organizer
      第43回日本毒性学会学術年会
    • Place of Presentation
      ウインクあいち(愛知県名古屋市)
    • Year and Date
      2016-06-29
    • Related Report
      2016 Research-status Report
  • [Presentation] NADPH-cytochrome P450 reductase- mediated denitration reaction of 2,4,6-trinitrotoluene to yield nitrite in mammals2016

    • Author(s)
      Shinkai Y, Kikuchi T, Kumagai Y
    • Organizer
      Society of Toxicology 55th Annual Meeting
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2016-03-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] トリニトロトルエンの脱ニトロ化反応におけるNADPH-チトクロムP450還元酵素の役割2015

    • Author(s)
      新開泰弘、中井由実、熊谷嘉人
    • Organizer
      第88回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] 環境化学物質の生体内運命とそれに対する防御応答の分子機構2015

    • Author(s)
      新開泰弘
    • Organizer
      フォーラム2015:衛生薬学・環境トキシコロジー
    • Place of Presentation
      神戸学院大学(神戸市)
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Presentation] カドミウムの防御応答に関わるHSP/HSF1経路の活性化と活性イオウ分子によるその制御.2015

    • Author(s)
      増田章、新開泰弘、熊谷嘉人
    • Organizer
      フォーラム2015:衛生薬学・環境トキシコロジー
    • Place of Presentation
      神戸学院大学(神戸市)
    • Year and Date
      2015-09-17
    • Related Report
      2015 Research-status Report
  • [Presentation] カドミウムによる親電子シグナル伝達経路の活性化と活性イオウ分子による修飾2015

    • Author(s)
      新開泰弘、鵜木隆光、鍜冶利幸、熊谷嘉人
    • Organizer
      第10回メタルバイオサイエンス研究会
    • Place of Presentation
      名古屋国際センター(名古屋市)
    • Year and Date
      2015-08-27
    • Related Report
      2015 Research-status Report
  • [Remarks] 筑波大学医学医療系環境生物学研究室

    • URL

      http://www.md.tsukuba.ac.jp/environmental_medicine/index.html

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
  • [Remarks] 筑波大学医学医療系 環境生物学研究室

    • URL

      http://www.md.tsukuba.ac.jp/environmental_medicine/index.html

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi