| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Cadmium has electrophilic property to modify cysteine residues in cellular proteins, resulting in its dysfunction and cytotoxicity. In this study, role of reactive sulfur species such as persulfides/polysulfides and ER stress response in protection against cadmium toxicity was examined. We found that cadmium induces enzymes associated with the production of reactive sulfur species. Also, reactive sulfur species were found to be protective against cadmium toxicity via formation of sulfur adducts of cadmium.
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