Role of reactive sulfur species and ER stress response in protection against cadmium toxicity
| Project/Area Number |
15K08042
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | カドミウム / 活性イオウ分子 / 小胞体ストレス応答 / イオウ付加体 / ポリスルフィド / 化学防御 / シスタチオニンγリアーゼ / シスタチオニンβシンターゼ |
|---|
| Outline of Final Research Achievements |
Cadmium has electrophilic property to modify cysteine residues in cellular proteins, resulting in its dysfunction and cytotoxicity. In this study, role of reactive sulfur species such as persulfides/polysulfides and ER stress response in protection against cadmium toxicity was examined. We found that cadmium induces enzymes associated with the production of reactive sulfur species. Also, reactive sulfur species were found to be protective against cadmium toxicity via formation of sulfur adducts of cadmium.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] 1,4-Naphthoquinone activates the HSP90/HSF1 pathway through the S-arylation of HSP90 in A431 cells: Negative regulation of the redox signal transduction pathway by persulfides/polysulfides2017
Author(s)
Abiko Y, Sha L, Shinkai Y, Unoki T, Luong NC, Tsuchiya Y, Watanabe Y, Hirose R, Akaike T, Kumagai Y.
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Journal Title
Free Radic Biol Med
Volume: 104
Pages: 118-128
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] NADPH-cytochrome P450 reductase-mediated denitration reaction of 2,4,6-trinitrotoluene to yield nitrite in mammals2016
Author(s)
Shinkai Y, Nishihara Y, Amamiya M, Wakayama T, Li S, Kikuch T, Nakai Y, Shimojo N, Kumagai Y
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Journal Title
Free Radical Biology and Medicine
Volume: 91
Pages: 178-187
DOI
Related Report
Peer Reviewed
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