Research on exposure to organic pollutants for the conservation of Japanese Red crowned crane

• Project/Area Number: 15K08043
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Environmental and hygienic pharmacy
• Research Institution: Kanazawa University
• Principal Investigator: Toriba Akira 金沢大学, 薬学系, 准教授 (50313680)
• Co-Investigator(Kenkyū-buntansha): 柿本 健作 地方独立行政法人 大阪健康安全基盤研究所, 企画部, 主任研究員 (40435889)
• Co-Investigator(Renkei-kenkyūsha): HAYAKAWA Kazuichi 金沢大学, 環日本海域環境研究センター, 特任教授 (40115267) ; TANG Ning 金沢大学, 環日本海域環境研究センター, 准教授 (90372490)
• Research Collaborator: MATSUMOTO Fumio 釧路市動物園, ツル担当・園長補佐 ; YOSHINO Tomoo 釧路市動物園, ツル担当・学芸担当・主事 ; TSUKUE Naomi 金沢大学, 環日本海域環境研究センター, 連携研究員
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: タンチョウ / 有機汚染物質 / 多環芳香族炭化水素 / 残留性有機汚染物質 / 生体曝露評価 / 曝露評価 / 有害化学物質

Outline of Final Research Achievements

Japanese Red-crowned crane inhabits the marsh in the eastern Hokkaido and it is classified as an endangered species. Nowadays, it lives near human beings and it is concerned that Red-crowned cranes are exposed to more anthropogenic chemical substances. Therefore, it is important to investigate the exposure levels of the chemicals for their protection. In this study, we determined the concentrations of persistent organic pollutants (POPs) in red-crowned crane muscle tissues and the concentrations were not high that their toxicities need to be considered. Furthermore, hydroxylated metabolites of polycyclic aromatic hydrocarbons (PAHs) excreted in the bile of the crane were successfully identified and quantified by using a developed analytical method. The biliary metabolites should be useful for the surveillance of exposure to PAHs.

Research Products

• [Journal Article] Persistent organic pollutants in red-crowned cranes (Grus japonensis) from Hokkaido, Japan (2018)
  • Author(s): Kakimoto Kensaku、Akutsu Kazuhiko、Nagayoshi Haruna、Konishi Yoshimasa、Kajimura Keiji、Tsukue Naomi、Yoshino Tomoo、Matsumoto Fumio、Nakano Takeshi、Tang Ning、Hayakawa Kazuichi、Toriba Akira
  • Journal Title: Ecotoxicology and Environmental Safety Volume: 147 Pages: 367-372
  • DOI: 10.1016/j.ecoenv.2017.08.060
  • Peer Reviewed
• [Journal Article] Personal inhalation exposure to polycyclic aromatic hydrocarbons and their nitro-derivatives in rural residents in northern Thailand (2017)
  • Author(s): Orakij Walaiporn、Chetiyanukornkul Thaneeya、Chuesaard Thanyarat、Kaganoi Yuichi、Uozaki Waka、Homma Chiharu、Boongla Yaowatat、Tang Ning、Hayakawa Kazuichi、Toriba Akira
  • Journal Title: Environmental Monitoring and Assessment Volume: 189 Issue: 10 Pages: 510-510
  • DOI: 10.1007/s10661-017-6220-z
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Simultaneous Determination of Polycyclic Aromatic Hydrocarbons and Their Nitro-derivatives in Airborne Particulates by Using Two-dimensional High-performance Liquid Chromatography with On-line Reduction and Fluorescence Detection (2017)
  • Author(s): Boongla Yaowatat、Orakij Walaiporn、Nagaoka Yuuki、Tang Ning、Hayakawa Kazuichi、Toriba Akira
  • Journal Title: Asian Journal of Atmospheric Environment Volume: 11 Issue: 4 Pages: 283-299
  • DOI: 10.5572/ajae.2017.11.4.283
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Polycyclic aromatic hydrocarbons and their nitro-derivatives from indoor biomass fueled cooking in two rural areas of Thailand: a case study. (2017)
  • Author(s): Orakij, W., Chetiyanukornkul, T., Kasahara, C., Boongla, Y., Chuesaard, T., Furuuchi, M., Hata, M., Tang, N., Hayakawa, K., Toriba, A.
  • Journal Title: Air Qual. Atmos. Health Volume: 印刷中 Issue: 6 Pages: 747-761
  • DOI: 10.1007/s11869-017-0467-y
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Size distribution of chlorinated polycyclic aromatic hydrocarbons in atmospheric particles (2017)
  • Author(s): K. Kakimoto, H. Nagayoshi, Y. Konishi, K. Kajimura, T. Ohura, T. Nakano, M. Hata, M. Furuuchi, N. Tang, K. Hayakawa, A. Toriba
  • Journal Title: Arch. Environ. Contam. Toxicol. Volume: 72 Issue: 1 Pages: 58-64
  • DOI: 10.1007/s00244-016-0327-z
  • Peer Reviewed
• [Journal Article] Recent analytical methods for atmospheric polycyclic aromatic hydrocarbons and their derivatives. (2017)
  • Author(s): Hayakawa, K., Tang, N., Toriba, A.
  • Journal Title: Biomed. Chromatogr. Volume: 31 Issue: 1
  • DOI: 10.1002/bmc.3862
  • Peer Reviewed
• [Journal Article] Simple method for determination of fungicides in citrus fruits by liquid chromatography-tandem mass spectrometry. (2016)
  • Author(s): Kakimoto, Y.*, Takatori, S., Okihashi, M., Kajimura, K., Toriba, A., Hayakawa, K.
  • Journal Title: Food Anal. Methods Volume: 9 Issue: 12 Pages: 3345-3351
  • DOI: 10.1007/s12161-016-0530-6
  • Peer Reviewed
• [Journal Article] Nitro-PAH exposures of occupationally-exposed traffic workers and associated urinary 1-nitropyrene metabolite concentrations (2016)
  • Author(s): J.P. Miller-Schulze, M. Paulsen, T. Kameda, A. Toriba, K. Hayakawa, B. Cassidy, L. Naeher, M.A. Villalobos, C.D. Simpson
  • Journal Title: J. Environ. Sci. Volume: 49 Pages: 213-221
  • DOI: 10.1016/j.jes.2016.06.007
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Simultaneous determination of polycyclic aromatic hydrocarbon quinones by gas chromatography-tandem mass spectrometry, following a one-pot reductive trimethysilyl derivatization (2016)
  • Author(s): A. Toriba, C. Homma, M. Kita, W. Uozaki, Y. Boongla, W. Orakij, N. Tang, T. Kameda, K. Hayakawa
  • Journal Title: J. Chromatogr. A Volume: 1459 Pages: 89-100
  • DOI: 10.1016/j.chroma.2016.06.034
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Dechlorane Plus and decabromodiphenyl ether in atmospheric particles of northeast Asian cities. (2015)
  • Author(s): Kakimoto, K., Nagayoshi, H., Akutsu, K., Konishi, Y., Kajimura, K., Hayakawa, K., Toriba, A.
  • Journal Title: Environ. Sci. Pollut. Res. Volume: 22 (19) Issue: 19 Pages: 14600-14605
  • DOI: 10.1007/s11356-014-2861-4
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Identification and characterization of oxidative metabolites of 1-chloropyrene. (2015)
  • Author(s): Kakimoto, K., Nagayoshi, H., Inazumi, N., Tani, A., Konishi, Y., Kajimura, K., Ohura, T., Nakano, T., Tang, N., Hayakawa, K., Toriba, A.
  • Journal Title: Chem. Res. Toxicol. Volume: 28（9） Issue: 9 Pages: 1728-1736
  • DOI: 10.1021/acs.chemrestox.5b00173
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] タンチョウの胆汁に排泄される多環芳香族炭化水素類の代謝物分析 (2018)
  • Author(s): 鳥羽陽，中谷沙織，机直美，吉野智生，松本文雄，唐寧，早川和一，鈴木 亮
  • Organizer: 日本薬学会第138年会
• [Presentation] 大気中の粒子状物質に含まれる多環芳香族炭化水素キノン類の粒径分布解析 (2017)
  • Author(s): 深川 真夢，長岡 祐樹，柿本 健作，唐 寧，早川 和一，鳥羽 陽
  • Organizer: 日本薬学会第137年会
  • Place of Presentation: 仙台国際センター（宮城県）
  • Year and Date: 2017-03-24
• [Presentation] Simultaneously determination of polycyclic aromatic hydrocarbons and their nitro-derivatives by using two-dimensional HPLC with on-line reduction and fluorescence detection (2017)
  • Author(s): Yaowatat Boongla，唐 寧，早川 和一，鈴木 亮，鳥羽 陽
  • Organizer: 日本分析化学会第66年会
• [Presentation] GC-MS/MSによる多環芳香族炭化水素キノン類の一斉分析法の開発と大気試料への適用 (2017)
  • Author(s): 鳥羽 陽，深川 真夢，唐 寧，早川 和一，鈴木 亮
  • Organizer: 日本分析化学会第66年会
• [Presentation] Development of an analytical method for simultaneously determining polycyclicaromatic hydrocarbons and their nitro-derivatives by high-performance liquidchromatography with fluorescence detection. (2016)
  • Author(s): Boongla, Y., Tang, N.,Hayakawa, K., Toriba, A.
  • Organizer: 18th International Conference of International Humic Substances Society
  • Place of Presentation: 金沢文化ホール（石川県）
  • Year and Date: 2016-09-11
  • Int'l Joint Research
• [Presentation] Characterization of polycyclic aromatic hydrocarbons and their nitro-derivativesfrom indoor wood burning in rural household Thailand. (2016)
  • Author(s): Orakij, W., Kasahara, C., Boongla, Y., Chuesaard, T., Chetiyanukornkul, T., Tang, N., Hayakawa, K.
  • Organizer: 18th International Conference of International Humic Substances Society
  • Place of Presentation: 金沢文化ホール（石川県）
  • Year and Date: 2016-09-11
  • Int'l Joint Research
• [Presentation] 大気粉塵の活性酸素種生成に対する多環芳香族炭化水素キノン類の寄与評価 (2016)
  • Author(s): 寺村 優希，本間 千春，唐 寧，早川 和一，鳥羽 陽
  • Organizer: フォーラム2016：衛生薬学・環境トキシコロジー
  • Place of Presentation: 昭和大学旗の台キャンパス（東京都）
  • Year and Date: 2016-09-10
• [Presentation] 生体曝露評価に利用できる多環芳香族炭化水素類の代謝物分析 (2016)
  • Author(s): 鳥羽 陽
  • Organizer: 第76回分析化学討論会
  • Place of Presentation: 岐阜薬科大学・岐阜大学（岐阜県）
  • Year and Date: 2016-05-28
• [Presentation] GC-MS/MS による大気粉塵中多環芳香族炭化水素キノン類の発生源評価 (2016)
  • Author(s): 本間千春，宇於崎和香，北 将大，唐 寧，早川和一，鳥羽 陽
  • Organizer: 日本薬学会第136年会
  • Place of Presentation: パシフィコ横浜（神奈川県）
  • Year and Date: 2016-03-26
• [Presentation] タンチョウの胆汁に排泄される多環芳香族炭化水素類の代謝物分析 (2016)
  • Author(s): 中谷 沙織，机 直美，吉野 智生，松本 文雄，唐 寧，早川 和一，鳥羽 陽
  • Organizer: 日本薬学会北陸支部第128回定例会
  • Place of Presentation: 北陸大学（石川県）
• [Presentation] 多環芳香族炭化水素キノン類による都市大気粉塵の活性酸素種産生への寄与評価 (2016)
  • Author(s): 寺村 優希，本間 千春，唐 寧，早川 和一，鳥羽 陽
  • Organizer: 日本薬学会北陸支部第128回定例会
  • Place of Presentation: 北陸大学（石川県）
• [Presentation] 生活環境において捕集したPM2.5に含まれる多環芳香族炭化水素類の粒径分布解析． (2015)
  • Author(s): 鳥羽 陽，加賀野井祐一，長岡祐樹，比嘉志歩，柿本健作，唐 寧，符 文華，斉 宏業，畑 光彦，古内正美，早川和一
  • Organizer: フォーラム2015：衛生薬学・環境トキシコロジー
  • Place of Presentation: 神戸学院大学ポートアイランドキャンパス（兵庫県）
  • Year and Date: 2015-09-17
• [Presentation] 塩素化多環芳香族炭化水素類のナノ粒子中における粒径分布の解明 (2015)
  • Author(s): 柿本健作，永吉晴奈，小西良昌，梶村計志，大浦健，畑 光彦，古内正美，唐 寧，早川和一，鳥羽 陽
  • Organizer: 第24回環境化学討論会
  • Place of Presentation: 札幌コンベンションセンター（北海道）
  • Year and Date: 2015-06-24
• [Book] Polycyclic Aromatic Hydrocarbons -Environmental Behavior and Toxicity in East Asia, Analytical Methods for Oxidative Derivatives of PAHs Including Application to Environmental and Biological Samples (2018)
  • Author(s): Toriba Akira et al., Hayakawa Kazuichi (Ed.)
  • Total Pages: 274
  • Publisher: Springer Nature
  • ISBN: 9789811067747
• [Remarks] 金沢大学衛生化学研究室ホームページ
  • URL: http://www.p.kanazawa-u.ac.jp/~eisei/j_home_framepage.html