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Analysis of molecular mechanisms for vascular endothelial perlecan synthesis by the strategy of bio-organometallices

Research Project

Project/Area Number 15K08047
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Environmental and hygienic pharmacy
Research InstitutionToho University

Principal Investigator

YAMAMOTO Chika  東邦大学, 薬学部, 教授 (70230571)

Co-Investigator(Kenkyū-buntansha) 鍜冶 利幸  東京理科大学, 薬学部薬学科, 教授 (90204388)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsプロテオグリカン / 血管内皮細胞 / バイオオルガノメタリクス / パールカン
Outline of Final Research Achievements

Bio-orgaometallics is a research strategy in which organic-inorganic hybrid molecules are used as a tool to analyze biological systems. Based on this strategy, we got hybrid molecules (1,10-phenanthroline with or without zinc or rhodium) from a library of organic-inorganic hybrid molecules. It was found that the expression of syndecan-4, a small heparan sulfate proteoglycan, is induced via the hypoxia-inducible factor-1α/β pathway when prolyl hydroxylase domain-containing protein 2 is inhibited.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (9 results)

All 2018 2017 2016

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (7 results)

  • [Journal Article] Synergistic cytotoxicity caused by forming a complex of copper and 2,9-dimethyl-1,10-phenanthroline in cultured vascular endothelial cells2017

    • Author(s)
      Nakamura T, Yoshida E, Fujie T, Ogata F, Yamamoto C, Kawasaki N, Kaji T
    • Journal Title

      The Journal of Toxicological Sciences

      Volume: 42 Issue: 6 Pages: 683-687

    • DOI

      10.2131/jts.42.683

    • NAID

      130006206268

    • ISSN
      0388-1350, 1880-3989
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytotoxicity of zinc, copper and rhodium complexes with 1,10-phenanthroline or 2,9-dimethyl-1,10-phenanthroline in cultured vascular endothelial cells2016

    • Author(s)
      Hara T, Matsuzaki H, Nakamura T, Yoshida E, Ohkubo T, Maruyama H, Yamamoto C, Saito S, Kaji T.
    • Journal Title

      Fundamental Toxicological Sciences

      Volume: 3 Issue: 3 Pages: 109-113

    • DOI

      10.2131/fts.3.109

    • NAID

      130005151853

    • ISSN
      2189-115X
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 亜鉛錯体による血管内皮細胞特異的なグリコサミノグリカン合成の調節2018

    • Author(s)
      原崇人,酒巻沙弥香,中村武浩,鍜冶利幸,山本千夏
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 銅錯体を用いた血管内皮細胞のプロテオグリカン発現調節機構の解析2017

    • Author(s)
      立石紘子,原崇人,吉田映子,藤江智也,山本千夏,中寛史,鍜冶利幸
    • Organizer
      第44回日本毒性学会学術年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 亜鉛錯体を用いた内皮細胞シンデカン-4の新規発現調節機構の解析2017

    • Author(s)
      原崇人,中村武浩,松崎紘佳,吉田映子,山本千夏,鍜冶利幸
    • Organizer
      第44回日本毒性学会学術年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ジチオカルバメート銅錯体Cu10による血管内皮細胞のシンデカン-4発現誘導2017

    • Author(s)
      立石紘子,原崇人,藤江智也,吉田映子,山本千夏,中寛史,鍜冶利幸
    • Organizer
      フォーラム2017:衛生薬学・環境トキシコロジー
    • Related Report
      2017 Annual Research Report
  • [Presentation] 鉛による血管内皮細胞増殖の阻害に関与するヘパラン硫酸プロテオグリカンの大型分子種パールカンの発現抑制機構2017

    • Author(s)
      熊谷玲衣奈,原崇人,吉田映子,藤原泰之,山本千夏,鍜冶利幸
    • Organizer
      フォーラム2017:衛生薬学・環境トキシコロジー
    • Related Report
      2017 Annual Research Report
  • [Presentation] ジチオカルバメート銅錯体による血管内皮細胞のプロテオグリカン発現調節2016

    • Author(s)
      立石紘子,原 崇人,藤江智也,吉田映子,山本千夏,中 寛史,鍜冶利幸
    • Organizer
      フォーラム2016 衛生薬学・環境トキシコロジー
    • Place of Presentation
      昭和大学旗の台キャンパス(東京都・品川区)
    • Year and Date
      2016-09-11
    • Related Report
      2016 Research-status Report
  • [Presentation] 有機ロジウム化合物を活用した血管内皮細胞のパールカン発現抑制機構の解明への試み2016

    • Author(s)
      松崎紘佳,原 崇人,吉田映子,藤原泰之,山本千夏,斎藤慎一,鍜冶利幸
    • Organizer
      フォーラム2016 衛生薬学・環境トキシコロジー
    • Place of Presentation
      昭和大学旗の台キャンパス(東京都・品川区)
    • Year and Date
      2016-09-11
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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