| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
To assess the relationship between the different pathological or clinical manifestations of Mycobacterium avium disease and bacterial factors, we mainly performed comparative genome analysis using clinical isolates from patients with various symptoms. Our analysis showed that M. avium strains which cause pulmonary and disseminated disease possess genetically distinct features. Comparative genome analysis of 79 M. avium strains comprising four subspecies revealed the presence of genetic elements specific to each lineage, and identified potential genetic determinants associated with not only the progression of pulmonary disease but also the host range characteristics of M. avium. Of note, this analysis indicated an association between the progression of pulmonary M. avium disease and several virulence genes including pMAH135. These results suggest that bacterial factors play an important role in the cause of the diverse pathological or clinical manifestations of M. avium disease.
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