Neuroprotective effect of fatty acid receptors in microglia
| Project/Area Number |
15K08050
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
Suzuki Kenji 立命館大学, 薬学部, 教授 (10187726)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 神経変性疾患 / 脂質メディエータ / ミクログリア / ケトン体 / 糖尿病 / GPCR / 細胞内情報伝達系 |
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| Outline of Final Research Achievements |
Many studies have suggested that type 2 diabetes is associated with an increased risk of several neurodegenerative diseases including Alzheimer’s disease (AD) and Parkinson’s diseases (PD). The ketogenic diet has been used for almost 100 years to treat refractory childhood epilepsy. It has also been studied as a potential therapy for other neurologic diseases, such as PD and AD. Hydroxycarboxylic acid receptor 2 (HCA2), also known as GPR109A, is a G protein-coupled anti-inflammatory receptor. It is present in macrophages, neutrophils and microglia. Beta-hydroxy butyrate (BHB) was identified as the physiological ligand of HCA2.
BHB suppressed LPS-induced expression of IL-6 and IL-1 beta in mouse microglia BV-2 cells. The phosphorylation of Erk1/2 was inhibited by the treatment of BHB, but the activation of the NF-kappa B pathway was not significantly influenced.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Simvastatin and atorvastatin facilitates amyloid β-protein degradation in extracellular spaces by increasing neprilysin secretion from astrocytes through activation of MAPK/Erk1/2 pathways.2016
Author(s)
Yamamoto, N., Fujii, Y., Kasahara, R., Tania, M., Ohora, K., Ono, Y., Suzuki, K. and Sobue, K.
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Journal Title
Glia
Volume: 64
Issue: 6
Pages: 952-962
DOI
Related Report
Peer Reviewed
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