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Elucidation of the metabolism and toxicity mechanism of arsenolipids by analytical chemistry techniques

Research Project

Project/Area Number 15K08058
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Environmental and hygienic pharmacy
Research InstitutionNational Institute for Environmental Studies

Principal Investigator

Kobayashi Yayoi  国立研究開発法人国立環境研究所, 環境リスク・健康研究センター, 主任研究員 (00391102)

Co-Investigator(Kenkyū-buntansha) 鈴木 紀行  千葉大学, 大学院薬学研究院, 准教授 (10376379)
小椋 康光  千葉大学, 薬学研究科(研究院), 教授 (40292677)
Project Period (FY) 2015-10-21 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsヒ素脂質 / 化学形態別分析 / HPLC-ICP-MS / LC-MS / 体内動態 / 代謝 / 血液脳関門 / HPLC-ICPMS
Outline of Final Research Achievements

Less information is available on the metabolism and toxicity of aresnolipids in mammals. Thus, we synthesized arsenic-containing hydrocarbon 332 (C17H38AsO) (AsHC332), 360 (AsHC360) (C19H42AsO) and arsenic fatty acid418 (C21H44AsO3) (AsFA418), and compared the tissue distribution and excretion of these arsenolipids with those of dimethylarsinic acid (DMAV) and trimethyl arsine oxide (TMAOV) after oral administration in mice. Approximately 77 to 94% of the dose were excreted from urine and feces in one day in the all groups. It was found that the recoveries of arsenic in the brain of AsHC332-, AsHC360-treated group, but not AsFA418-tretated group, were higher than that of DMAV-treated group, namely, approximately 2 and 4 times, respectively. The higher accumulation of arsenic originating AsHC332 and AsHC360 in brain suggests that AsHC is easier permeable across the blood-brain barrier than DMAV.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (3 results)

All 2017 2016

All Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] 質量分析法に基づくヒ素脂質の代謝および毒性機構の解明 第2報 ~ヒ素脂質経口投与後のマウスにおけるヒ素の分布と排泄~2017

    • Author(s)
      小林弥生,鈴木紀行,小椋康光,平野靖史郎
    • Organizer
      フォーラム2017:衛生薬学・環境トキシコロジー
    • Related Report
      2017 Annual Research Report
  • [Presentation] Distribution and excretion of arsenic in mice after oral administration of arsenolipid2017

    • Author(s)
      Kobayashi Y., Suzuki N., Ogra Y., Hirano S.
    • Organizer
      The 6th International Symposium on Metallomics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 質量分析法に基づくヒ素脂質の代謝および毒性機構の解明 第 1 報 ~分析および抽出手法の検討~2016

    • Author(s)
      小林弥生、 鈴木紀行、 小椋康光、平野靖史郎
    • Organizer
      フォーラム2016:衛生薬学・環境トキシコロジー
    • Place of Presentation
      昭和大学旗の台キャンパス(東京)
    • Year and Date
      2016-09-10
    • Related Report
      2016 Research-status Report

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Published: 2015-10-21   Modified: 2019-03-29  

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