| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
In recent years, the importance of the percutaneous sensitization route in food allergy onset has been pointed out. This study was conducted for the purpose of analysis of the mechanism of skin sensitization by food allergens and the search for marker molecules. Transdermal sensitization with food allergens was performed using mice, and immune response was analyzed. As a result, IgE-producing B cells, follicular helper T cells, and CD207 (Langerin)-positive dendritic cells which are thought to have migrated from the skin were increased in the regional lymph nodes close to the sensitization site. This study showed an outline of the immune response in transdermal sensitization and the candidate for marker molecules.
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