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Degradation of glycosaminoglycans in cerebral infarction

Research Project

Project/Area Number 15K08068
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical pharmacy
Research InstitutionChiba University

Principal Investigator

Higashi Kyohei  千葉大学, 大学院薬学研究院, 助教 (10463829)

Co-Investigator(Renkei-kenkyūsha) Toida Toshihiko  千葉大学, 大学院薬学研究院, 教授 (60163945)
IGARASHI Kazuei  千葉大学, 大学院薬学研究院, 名誉教授研究 (60089597)
FURIHATA Tomomi  千葉大学, 大学院医学研究院, 講師 (80401008)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords糖衣 / ヘパラン硫酸 / コンドロイチン硫酸 / 脳梗塞 / 酸化ストレス / アクロレイン / ヘパラナーゼ / ヒアルロニダーゼ / ヘパリン / MMP9 / 脳虚血
Outline of Final Research Achievements

In this study, we observed that heparan sulfate (HS) and chondroitin sulfate (CS) were degraded in ischemic brain lesion. In addition, increased level of heparanase 1 (HPSE1), hyaluronidase (HYAL1) and HYAL4 were observed. When low molecular weight of heparin and CS together with N-acetylcysteine (NAC), a free radical scavenger were administrated to photochemically induced thrombosis model mice, infarct area was decreased compared with NAC only group. These results suggest that not only oxidative stress but also degradation of HS and CS in glycocalyx of endothelial cells are important for the ischemic brain infarction.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (55 results)

All 2018 2017 2016 2015 Other

All Journal Article (18 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 14 results,  Acknowledgement Compliant: 3 results,  Open Access: 2 results) Presentation (32 results) (of which Int'l Joint Research: 7 results,  Invited: 2 results) Remarks (2 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 1 results)

  • [Journal Article] Reduction of Spermidine Content Resulting from Inactivation of Two Arginine Decarboxylases Increases Biofilm Formation in Synechocystis sp. PCC 68032018

    • Author(s)
      Kota Kera, Tatsuya Nagayama, Kei Nanatani, Chika Saeki-Yamoto, Akira Tominaga, Satoshi Souma, Nozomi Miura, Kota Takeda, Syunsuke Kayamori, Eiji Ando, Kyohei Higashi, Kazuei Igarashi and Nobuyuki Uozumi
    • Journal Title

      Journal of Bacteriology

      Volume: 9 Issue: 9 Pages: 664-706

    • DOI

      10.1128/jb.00664-17

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive analysis of glycosaminoglycans from the edible shellfish.2018

    • Author(s)
      Okamoto Y, Higashi K, Linhardt RJ, Toida T.
    • Journal Title

      Carbohydr. Polym.

      Volume: 184 Pages: 269-276

    • DOI

      10.1016/j.carbpol.2017.12.076

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sequencing the Dermatan Sulfate Chain of Decorin.2017

    • Author(s)
      Yu Y, Duan J, Leach FE 3rd, Toida T, Higashi K, Zhang H, Zhang F, Amster IJ, Linhardt RJ.
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 139 Issue: 46 Pages: 16986-16995

    • DOI

      10.1021/jacs.7b10164

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Determination of 3-hydroxypropylmercapturic acid in urine by three column-switching high-performance liquid chromatography with electrochemical detection using a diamond electrode.2017

    • Author(s)
      Higashi K, Shibasaki M, Kuni K, Uemura T, Waragai M, Uemura K, Igarashi K, Toida T.
    • Journal Title

      J. Chromatogr. A

      Volume: 1517 Pages: 79-85

    • DOI

      10.1016/j.chroma.2017.08.030

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heparan Sulfate Alterations in Extracellular Matrix Structures and FGF-2 Signaling Impairment in the Aged Neurogenic Niche.2017

    • Author(s)
      Yamada T, Kerever A, Yoshimura Y, Suzuki Y, Nonaka R, Higashi K, Toida T, Mercier F, Arikawa-Hirasawa E.
    • Journal Title

      J Neurochem.

      Volume: 142 Issue: 4 Pages: 534-544

    • DOI

      10.1111/jnc.14081

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of the Partially Methylated Alditol Acetates Derived from CS Tetrasaccharides Containing Galactose for the Gas Chromatography/Mass Spectrometry Analysis.2017

    • Author(s)
      Higashi K, Toida T.
    • Journal Title

      Bio. Protoc.

      Volume: - Issue: 21

    • DOI

      10.21769/bioprotoc.2600

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Isolation of Keratan Sulfate Disaccharide-branched Chondroitin Sulfate E from Mactra chinensis.2017

    • Author(s)
      Higashi K, Toida T.
    • Journal Title

      Bio. Protoc.

      Volume: - Issue: 15

    • DOI

      10.21769/bioprotoc.2441

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 天然物由来コンドロイチン硫酸の網羅的解析2017

    • Author(s)
      東恭平, 戸井田敏彦
    • Journal Title

      Foods& Food Ingredients J. Jpn.

      Volume: 222 Pages: 19-26

    • NAID

      40021105436

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
  • [Journal Article] 硬骨魚類スズキ (Lateolabrax japonicas)に含まれるコンドロイチン硫酸の二糖組成解析2017

    • Author(s)
      東恭平, 今村正隆, 岡本悠佑, 戸井田敏彦.
    • Journal Title

      応用糖質科学

      Volume: in press

    • NAID

      40021218331

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A novel putrescine exporter SapBCDF of Escherichia coli.2016

    • Author(s)
      Y. Sugiyama, A. Nakamura, M. Matsumoto, A. Kanbe, H. Suzuki, M. Sakanaka, K. Higashi, K. Igarashi, T. Katayama, and S. Kurihara.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 291 Issue: 51 Pages: 26343-26351

    • DOI

      10.1074/jbc.m116.762450

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of keratan sulfate disaccharide at C-3 position of glucuronate of chondroitin sulfate from Mactra chinensis.2016

    • Author(s)
      Higashi K, Takeda K, Mukuno A, Okamoto Y, Masuko S, Linhardt RJ, Toida T.
    • Journal Title

      Biochem J.

      Volume: 473 Issue: 22 Pages: 4145-4158

    • DOI

      10.1042/bcj20160655

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Polyamines release the let-7b-mediated suppression of initiation codon recognition during the protein synthesis of EXT2.2016

    • Author(s)
      Imamura M, Higashi K, Yamaguchi K, Asakura K, Furihata T, Terui Y, Satake T, Maegawa J, Yasumura K, Ibuki A, Akase T, Nishimura K, Kashiwagi K, Linhardt RJ, Igarashi K, Toida T
    • Journal Title

      Sci. Rep.

      Volume: 6 Issue: 1 Pages: 33549-33549

    • DOI

      10.1038/srep33549

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Molecular mechanism underlying promiscuous polyamine recognition by spermidine acetyltransferase2016

    • Author(s)
      S. Sugiyama, S. Ishikawa, H. Tomitori, M. Niiyama, M. Hirose, Y. Miyazaki, K. Higashi, M. Murata, H. Adachi, K. Takano, S. Murakami, T. Inoue, Y. Mori, K. Kashiwagi, K. Igarashi, H. Matsumura
    • Journal Title

      Int. J. Biochem. Cell Biol.

      Volume: 76 Pages: 87-97

    • DOI

      10.1016/j.biocel.2016.05.003

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recent Progress in Analytical Methods for Determination of Urinary 3-Hydroxypropylmercapturic Acid, a Major Metabolite of Acrolein2016

    • Author(s)
      Higashi K, Igarashi K, Toida T.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 39 Issue: 6 Pages: 915-919

    • DOI

      10.1248/bpb.b15-01022

    • NAID

      130005155127

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2016 Research-status Report 2015 Research-status Report
  • [Journal Article] Poly-ion complex of chondroitin sulfate and spermine and its effect on oral chondroitin sulfate bioavailability.2016

    • Author(s)
      Ge D, Higashi K, Ito D, Nagano K, Ishikawa R, Terui Y, Higashi K, Moribe K, Linhardt RJ and Toida T.
    • Journal Title

      Chem. Pharm. Bull.

      Volume: in press

    • NAID

      130005148753

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Association between components of exudates and periwound moisture-associated dermatitis in breast cancer patients with malignant fungating wounds.2016

    • Author(s)
      Tamai N, Akase T, Minematsu T, Higashi K, Toida T, Igarashi K, Sanada H.
    • Journal Title

      Biol. Res. Nurs.

      Volume: 18 Issue: 2 Pages: 199-206

    • DOI

      10.1177/1099800415594452

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Functional chondroitin sulfate from Enteroctopus dofleini containing a 3-O-sulfo glucuronic acid residue.2015

    • Author(s)
      Higashi K, Okamoto Y, Mukuno A, Wakai J, Hosoyama S, Linhardt RJ and Toida T.
    • Journal Title

      Carbohydr. Polym.

      Volume: 134 Pages: 557-565

    • DOI

      10.1016/j.carbpol.2015.07.082

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Spermidine and Ca2+, but not Na+, can permeate NMDA receptors consisting of GluN1 and GluN2A or GluN2B in the presence of Mg2+.2015

    • Author(s)
      Hirose T, Saiki R, Yoshizawa Y, Imamura M, Higashi K, Ishii I, Toida T, Williams K, Kashiwagi K, Igarashi K.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 463 Issue: 4 Pages: 1190-1195

    • DOI

      10.1016/j.bbrc.2015.06.081

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 脳梗塞急性期におけるグリコサミノグリカン損傷機構の解明2018

    • Author(s)
      服部 奈津子, 東 恭平, 高 健太, 石川 涼太, 梅原 健太, 降幡 知巳, 五十嵐 一衛, 戸井田 敏彦
    • Organizer
      日本薬学会第138年会 (金沢)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 蛍光HPLCによる香粧品中アセチルヒアルロン酸およびヒアルロン酸の定量分析2018

    • Author(s)
      短田 優菜, 東 恭平, 安井 千晶, 戸井田 敏彦
    • Organizer
      日本薬学会第138年会 (金沢)
    • Related Report
      2017 Annual Research Report
  • [Presentation] ポリアミンとヘパリンの相互作用に基づくヘパリン徐放性製剤の創出.2017

    • Author(s)
      伊藤 大地, 東 恭平, 葛 丹, 照井 祐介, 戸井田 敏彦
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Related Report
      2016 Research-status Report
  • [Presentation] ポリアミンによるグリコサミノグリカン合成調節機構の解明.2017

    • Author(s)
      今村 正隆, 東 恭平, 山口 勝利, 朝倉 希里生, 降幡 知巳, 照井 祐介, 佐武 利彦, 前川 二郎, 安村 和則, 伊吹 愛, 赤瀬 智子, 西村 和洋, 柏木 敬子, Robert J.Linhardt, 五十嵐 一衛, 戸井田 敏彦
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Related Report
      2016 Research-status Report
  • [Presentation] 脳梗塞急性期における糖衣分解機構の解明.2017

    • Author(s)
      石川 涼太, 東 恭平, 服部 奈津子, 望月 龍, 今村 正隆, 伊藤 大地, 降幡 知己, 五十嵐 一衛, 戸井田 敏彦
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Related Report
      2016 Research-status Report
  • [Presentation] 貝類に含まれるコンドロイチン硫酸の網羅的解析.2017

    • Author(s)
      岡本 悠佑, 東 恭平, 戸井田 敏彦
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Related Report
      2016 Research-status Report
  • [Presentation] 加齢による脳 梗塞悪化とアクロレインの関係並びに新規脳保護薬の開発.2017

    • Author(s)
      渡辺 健太, 植村 武史, 東 恭平, 小暮 紀行, 北島 満里子, 高山 廣光, 高尾 浩一, 杉田 義昭, 西村 和洋, 五十嵐 一衛, 戸井田 敏彦
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Related Report
      2016 Research-status Report
  • [Presentation] ポリアミンによるコンドロイチン硫酸合成調節機構の解明2017

    • Author(s)
      朝倉 希里生, 東 恭平, 今村 正隆, 山口 勝利, 降幡 知巳, 西村 和洋, 五十嵐 一衛, 戸井田 敏彦
    • Organizer
      日本薬学会第138年会 (金沢)
    • Related Report
      2017 Annual Research Report
  • [Presentation] メチレンブルーを用いた硫酸基含有グリコサミノグリカンの簡易定量法2017

    • Author(s)
      岡本 悠祐, 東 恭平, 真野 貴, 和田 竜哉, 戸井田 敏彦
    • Organizer
      日本薬学会第138年会 (金沢)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 硬骨魚類スズキ (Lateolabrax japonicas)に含まれるコンドロイチン硫酸の二糖組成解析.2017

    • Author(s)
      東 恭平,今村 正隆,岡本 悠佑,戸井田 敏彦
    • Organizer
      第36回日本糖質学会年会 (旭川)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 硬骨魚類スズキ (Lateolabrax japonicas)に含まれるコンドロイチン硫酸の二糖組成解析.2017

    • Author(s)
      東 恭平,今村 正隆,岡本 悠佑,戸井田 敏彦
    • Organizer
      日本食品化学学会 第23回総会・学術大会 (志摩磯部)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Polyamines reverse the RNA G-quadruplex mediated inhibition during the translation initiation of chondroitin synthase-12017

    • Author(s)
      Higashi K, Yamaguchi K, Imamura M, Asakura K, Furihata T, Nishimura K, Sakamoto T, Linhardt RJ, Igarashi K, and Toida T
    • Organizer
      Gordon research conference on polyamines (Waterville Valley, NH, USA)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 天然物由来コンドロイチン硫酸の構造解析2017

    • Author(s)
      東 恭平
    • Organizer
      第5回大学連携研究設備ネットワーク研究成果報告会
    • Place of Presentation
      千葉大学西千葉キャンパス
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] ポリアミンによるコンドロイチン硫酸合成調節機構の解明.2016

    • Author(s)
      朝倉 希里生, 東 恭平, 今村 正隆, 山口 勝利, 降幡 知己, 西村 和洋, 五十嵐 一衛, 戸井田 敏彦
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台
    • Year and Date
      2016-09-25
    • Related Report
      2016 Research-status Report
  • [Presentation] ケラタン硫酸二糖の枝分かれ構造を有するコンドロイチン硫酸の同定.2016

    • Author(s)
      東 恭平, 武田 圭太, 向野 杏, 岡本 悠祐, Linhardt RJ, 戸井田 敏彦
    • Organizer
      第35回日本糖質学会年会
    • Place of Presentation
      高知
    • Year and Date
      2016-09-01
    • Related Report
      2016 Research-status Report
  • [Presentation] Polyamines release the let-7b-mediated suppression of initiation codon recognition during the protein synthesis of EXT2.2016

    • Author(s)
      Kyohei Higashi, Masataka Imamura, Katsutoshi Yamaguchi, Kiryu Asakura, Tomomi Furihata, Yusuke Terui, Toshihiko Satake, Jiro Maegawa, Kazunori Yasumura, Ai Ibuki, Tomoko Akase, Kazuhiro Nishimura, Keiko Kashiwagi, Robert J. Linhardt, Kazuei Igarashi & Toshihiko Toida.
    • Organizer
      Gordon Research Conference (Proteoglycans)
    • Place of Presentation
      Andover, NH, USA.
    • Year and Date
      2016-07-10
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 食品に含まれるコンドロイチン硫酸の解析並びにその生理活性に関する研究2016

    • Author(s)
      東 恭平
    • Organizer
      日本食品化学学会第22回総会・学術大会
    • Place of Presentation
      高知
    • Year and Date
      2016-06-02
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 脳梗塞急性期におけるヘパラン硫酸分解機構の解明.2016

    • Author(s)
      石川 涼太, 東 恭平, 服部 奈津子, 降幡 知巳, 藤吉 正哉, 石井 伊都子, 五十嵐 一衛, 戸井田 敏彦.
    • Organizer
      日本薬学会 第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] ポリアミンによるコンドロイチン硫酸合成調節機構の解明2016

    • Author(s)
      山口勝利, 東 恭平, 今村 正隆, 西村 和洋, 柏木 敬子, 五十嵐 一衛, 戸井田 敏彦.
    • Organizer
      日本薬学会 第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 機能性食品含有プロテオグリカンおよびグリコサミノグリカンの分別定量.2016

    • Author(s)
      岡本悠祐, 東 恭平, 真野 貴, 和田 竜哉, 戸井田 敏彦.
    • Organizer
      日本薬学会 第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 急性期脳梗塞時におけるヘパラン硫酸分解機構の解明.2016

    • Author(s)
      石川 涼太, 東 恭平, 服部 奈津子, 降幡 知巳, 藤吉 正哉, 石井 伊都子, 五十嵐 一衛, 戸井田 敏彦.
    • Organizer
      千葉大学リーディング研究育成プログラム「細胞間クロノ・コミュニケーション」 シンポジウム 「時間軸から迫る脳機能」
    • Place of Presentation
      千葉
    • Year and Date
      2016-03-08
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] アオヤギ貝腸由来コンドロイチン硫酸の構造解析2015

    • Author(s)
      武田圭太、東恭平、向野杏、鈴木翔、細山沙織、戸井田敏彦
    • Organizer
      第88回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] 糖尿病合併症に対する生体内ポリアミンの防御作用2015

    • Author(s)
      松本靖彦,東恭平,石井雅樹、五十嵐一衛,関水和久
    • Organizer
      第88回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] スペルミジンとCa2+はMg2+存在下においてもNMDA受容体を透過できる.2015

    • Author(s)
      廣瀬 直雄、東 恭平、斎木 遼太郎、吉沢 祐基、今村 正隆、石井 伊都子、戸井田 敏彦、Williams, Keith、柏木 敬子、五十嵐 一衛
    • Organizer
      第88回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] Preparation of Poly-ion Complex Generated from Chondroitin Sulfate and Polyamines and its Effect on Oral Bioavailabity2015

    • Author(s)
      Ge D, Higashi K, Ito D, Terui Y, Nagano K,Ishikawa R, and Toida T
    • Organizer
      日本ポリアミン学会第7回年会
    • Place of Presentation
      京都
    • Year and Date
      2015-11-13
    • Related Report
      2015 Research-status Report
  • [Presentation] ポリアミンとヘパリンの相互作用に基づくポリイオンコンプレックスの形成とその物性評価2015

    • Author(s)
      伊藤大地、東恭平、葛丹、戸井田敏彦
    • Organizer
      「ポリアミンと核酸の共進化」第14回合同シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2015-09-12
    • Related Report
      2015 Research-status Report
  • [Presentation] Chondroitin Sulfate Proteoglycans from Salmon Nasal Cartilage: A New Nutraceutical for Treatment of OA.2015

    • Author(s)
      Higashi K, Okamoto Y, Takeda K, Suabjakayong P, Mano T, Wada T and Toida T.
    • Organizer
      9th International Conference on Proteoglycans and 10th Pan-Pacific Connective Tissue Societies Symposium
    • Place of Presentation
      Ewha Womens University, Seoul, Korea
    • Year and Date
      2015-08-23
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 小分子蛍光物質を用いた蛍光標識グリコサミノグリカンの調整と有用性評価2015

    • Author(s)
      短田優奈、東恭平、萩原裕樹、伊藤大地、今村正隆、戸井田敏彦
    • Organizer
      第34回日本糖質学会年会
    • Place of Presentation
      東京
    • Year and Date
      2015-07-31
    • Related Report
      2015 Research-status Report
  • [Presentation] Preparation of Poly-ion Complex Generated from Spermine and its Effect on Oral Intake2015

    • Author(s)
      Dan Ge, Kyohei Higashi, Daichi Ito and Toshihiko Toida
    • Organizer
      Gordon Research Conference (Polyamines)
    • Place of Presentation
      Waterville Valley, NH, USA
    • Year and Date
      2015-06-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of polyamines on the synthesis of chondroitin sulfate in mammalian cells2015

    • Author(s)
      Higashi K, Yamaguchi K, Imamura M, Furihata T, Terui Y, Kashiwagi K, Linhardt RJ, Igarashi K, and Toida T
    • Organizer
      Gordon Research Conference (Polyamines)
    • Place of Presentation
      Waterville Valley, NH, USA
    • Year and Date
      2015-06-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Polyamines increase in response to hyperglycemia and protect organisms from sugar toxicity.2015

    • Author(s)
      Matsumoto Y, Higashi K, Ishii M, Igarashi K and Sekimizu K.
    • Organizer
      Gordon Research Conference (Polyamines)
    • Place of Presentation
      Waterville Valley, NH, USA
    • Year and Date
      2015-06-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 食用貝に含まれるコンドロイチン硫酸とその生理機能2015

    • Author(s)
      東恭平,岡本悠佑, 武田圭太, 伊藤大地, 戸井田敏彦
    • Organizer
      日本食品化学学会 第21回総会・学術大会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-20
    • Related Report
      2015 Research-status Report
  • [Remarks] 千葉大学大学院薬学研究院病態分析化学研究室

    • URL

      http://www.p.chiba-u.jp/lab/bunseki/index.html

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
  • [Remarks] 病態分析化学研究室

    • URL

      http://www.p.chiba-u.jp/lab/bunseki/index.html

    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] ヘパリンの会合体2018

    • Inventor(s)
      東恭平
    • Industrial Property Rights Holder
      東恭平
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2017 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] ヘパリンの会合体2017

    • Inventor(s)
      東恭平
    • Industrial Property Rights Holder
      東恭平
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-039560
    • Filing Date
      2017-03-02
    • Related Report
      2016 Research-status Report
  • [Patent(Industrial Property Rights)] コンドロイチン/デルマタン硫酸並びにこれを含む抗炎症剤、保湿剤及び抗血液凝固剤2016

    • Inventor(s)
      東恭平
    • Industrial Property Rights Holder
      東恭平
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-170377
    • Filing Date
      2016-08-31
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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