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Prediction of interindividual variations in pain relief and adverse effects of opioid analgesics based on cancer disease stage

Research Project

Project/Area Number 15K08070
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical pharmacy
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

Kawakami Junichi  浜松医科大学, 医学部附属病院, 教授 (50272539)

Co-Investigator(Kenkyū-buntansha) 内藤 隆文  浜松医科大学, 医学部附属病院, 特任准教授 (80422749)
Research Collaborator ISHIDA Takuya  浜松医科大学, 医学部附属病院, 薬剤師
TANAKA Hironari  浜松医科大学, 医学部附属病院, 薬剤師
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsがん病期 / オピオイド / 炎症性サイトカイン / 薬物動態 / 有害作用 / 鎮痛効果 / がん性疼痛 / 病期 / トラマドール / 薬物代謝 / 忍容性 / フェンタニル / 鎮痛補助薬 / プレガバリン / がん悪液質
Outline of Final Research Achievements

Cancer patients have a large variation in clinical responses to opioid analgesics at each cancer disease stage. Plasma exposure of and clinical responses to opioid analgesics are potentially influenced by the genetic factors including genetic variants of drug metabolizing enzyme and non-genetic factors including gender and physiological changes accompanied with cancer progression. This study evaluated the relationships between the plasma exposure of and clinical responses to opioid analgesics including transdermal fentanyl and oral tramadol, drug tolerance, and adverse effects at each cancer disease stage. In this study, the cancer disease stages employed the serum inflammation markers including IL-6 and CRP, and cancer symptom- and inflammation-based scores. From the cross-sectional analyses for cancer patients, this study revealed the interindividual factors related to the pharmacokinetics of opioid analgesics, pain relief, and adverse effects based on cancer disease stages.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2017

All Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Impact of CYP2D6 phenotype on tramadol pharmacokinetics and metabolic pathways in cancer patients2017

    • Author(s)
      Tanaka H, Naito T, Sato H, Kawakami J
    • Organizer
      13th Congress of the European Association for Clinical Pharmacology and Therapeutics (EACPT2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] がん患者におけるトラマドールとその脱メチル代謝物の血中動態に及ぼすCYP2D6およびCYP2B6の遺伝子変異の影響2017

    • Author(s)
      田中達也, 内藤隆文, 佐藤聖, 川上純一
    • Organizer
      第38回日本臨床薬理学会年会
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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