Mechanism of anti-inflammatory action of self-assembling heparion nanoparticles
Project/Area Number |
15K08071
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Medical pharmacy
|
Research Institution | Kyoto University |
Principal Investigator |
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | ヘパリン誘導体 / 抗炎症反応 / 数理モデリング / 転写因子 / 因子分析 / マイクロアレイ解析 / テキストマイニング |
Outline of Final Research Achievements |
When non-anticoagulant heparin is conjuated with aliphatic amines, it comes to form self-assembling nanomicelles and exhibit remarkable suppressive effect on the production of proinflammatory cytokines in lipopolysaccharide(LPS)-stimulated macrophages. The present study demonstrated that the anti-inflammatory effect can be observed with not only heparin but other glycosaminoglycans, being stronger as their degree of sulfation is higher. In addition, the time-series data of expression of a variety of genes following LPS stimulation were analyzed based on a mathematical model. The quantitative transcription network analysis indicated that the heparin nanoparticles appeared to selectively inhibit the activation of TAK1-IKK-NFkappaB pathway following LPS stimulation.
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Report
(4 results)
Research Products
(7 results)