| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
The basic knowledge indispensable for designing the local application type DDS, which provides the localized pharmaceutical activities of drugs, was investigated by the ap-plication of microdialysis technique (MD). The localized diffusion process of topically applied model drug was monitored by MD and thus determined a focal availability concept for the local application type DDS was discussed. To improve the percutaneous absorption of drugs, solid-dispersions for low-water soluble drugs and L-HPC hydrogel sheet for dressing materials were investigated.
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