Dosage design and its evaluation for topically applicable DDS by focal unbound drug concentration monitoring
Project/Area Number |
15K08073
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Medical pharmacy
|
Research Institution | Okayama University |
Principal Investigator |
Kurosaki Yuji 岡山大学, 医歯薬学総合研究科, 教授 (90161786)
|
Co-Investigator(Renkei-kenkyūsha) |
KIM Hye-Sook 岡山大学, 大学院医歯薬学総合研究科, 准教授 (70314664)
|
Project Period (FY) |
2015-10-21 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 局所適用型DDS / 局所薬物動態モニタリング / マイクロダイアリシス / 吸着動態補正 / 固体分散体 / 含水ゲルシート / 微小透析 / 局所薬物動態 / デコンボリューション |
Outline of Final Research Achievements |
The basic knowledge indispensable for designing the local application type DDS, which provides the localized pharmaceutical activities of drugs, was investigated by the ap-plication of microdialysis technique (MD). The localized diffusion process of topically applied model drug was monitored by MD and thus determined a focal availability concept for the local application type DDS was discussed. To improve the percutaneous absorption of drugs, solid-dispersions for low-water soluble drugs and L-HPC hydrogel sheet for dressing materials were investigated.
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Report
(4 results)
Research Products
(4 results)