Study on the mechanism of epithelial-mesenchymal transition as a cause of drug-induced lung injury, and development of the strategy for preventing the injury
| Project/Area Number |
15K08074
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Hiroshima University |
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Principal Investigator |
Ryoko Yumoto 広島大学, 医歯薬保健学研究科(薬), 准教授 (70379915)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKANO Mikihisa 広島大学, 大学院医歯薬保健学研究科, 教授 (20211336)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 薬物動態学 / 薬剤性肺障害 / 肺胞上皮細胞 / 上皮間葉転換 / TGF-β1 / quercetin / 肺胞上皮細 / 薬学 |
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| Outline of Final Research Achievements |
Many drugs used in clinical pharmacotherapy often induce serious injury of the lungs and sometimes result in lethal interstitial lung diseases. Though there is a great variation in the reported values about the prevalence of drug-induced lung diseases, it is high especially in the case of bleomycin. It is now recognized that epithelial-mesenchymal transition (EMT) plays an essential role in the fibrosis of various organs and is acknowledged to be one of the mechanisms underlying the generation of mesenchymal cells participating in tissue fibrosis.
In this study, we have found that RLE/Abca3 cells is a good in-vitro model to study drug-induced EMT, and TGF-β1 would be involved in the mechanism underlying bleomycin-induced EMT. In addition, quercetin, a flavonoid, may be a good therapeutic agent for drug-induced lung injury, which inhibits the intracellular ROS production and the TGF-β/smad pathway.
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Report
(4 results)
Research Products
(67 results)
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[Journal Article] Effect of COA-Cl on transforming growth factor-β1-induced epithelial-mesenchymal transition in RLE/Abca3 cells.2017
Author(s)
Kawami, M., Deguchi, J., Yumoto, R., Sakakibara, N., Tsukamoto, I., Konishi,R., Takano, M.
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Journal Title
Drug Metabolism and Pharmacokinetics
Volume: 32
Pages: 224-227
NAID
Related Report
Peer Reviewed
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[Journal Article] Current progress toward a better understanding of drug disposition within the lungs: summary proceedings of the 1st Workshop on Drug Transporters in the Lungs.2017
Author(s)
Ehrhardt C, Beckman P, Couet W, Edwards C, Forbes B, Friden M, Gumbleton M, Hosoya KI, Kato Y, Nakanishi T, Takano M, Terasaki T, Yumoto R
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Journal Title
J Pharm Sci
Volume: 未定
Issue: 9
Pages: 2234-2244
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Effect of Curcuma comosa extracts on the functions of peptide transporter and P-glycoprotein in intestinal epithelial cell.2017
Author(s)
Kawami, M., Yamada, Y., Toshimori, F., Issarachot, O., Junyaprasert, V.B., Yumoto, R., Takano, M.
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Journal Title
Pharmazie
Volume: 72
Pages: 123-127
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Cisplatin resistance in human lung cancer cells is linked with dysregulation of cell cycle associated proteins.2015
Author(s)
Horibe S, Matsuda A, Tanahashi T, Inoue J, Kawauchi S, Mizuno S, Ueno M, Takahashi K, Maeda Y, Maegouchi T, Murakami Y, Yumoto R, Nagai J, Takano M.
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Journal Title
Life Sciences
Volume: １２４
Pages: 31-40
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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