| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
This research is based on "the complete elucidation of the endogenous transport system of physiologically active gases by HSA and its clinical application", and the generation mechanism of modifications with NO or H2S have been clarified. As a result, it was inferred that crosstalk between NO and H2S. Also, in the measurement of Cysteine persulfide, it was confirmed that an oxidized form of polysulfide was abundantly present in HSA by the newly developed measurement method, and this oxidized form of polysulfide reacts sensitively to oxidative stress It was also possible to clarify that it changes from the early stage of the disease state.
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