Organ-specific inactivation of cancer multidrug resistance by regulating membrane scaffold proteins
| Project/Area Number |
15K08078
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Takasaki University of Health and Welfare |
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Principal Investigator |
Ogihara Takuo 高崎健康福祉大学, 薬学部, 教授 (80448886)
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| Co-Investigator(Kenkyū-buntansha) |
矢野 健太郎 高崎健康福祉大学, 薬学部, 助教 (40644290)
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| Co-Investigator(Renkei-kenkyūsha) |
Arakawa Hiroshi 金沢大学, 医薬保健研究域薬学系, 助教 (40709028)
Idota Yoko 高崎健康福祉大学, 薬学部, 研究員 (90629594)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | P-gp / BCRP / MRPｓ / 網羅的な阻害 / 足場タンパク / がん組織 / 排出系トランスポーター / 多剤耐性 / MRPs / P-糖たんぱく / MRP / 腎臓がん / 消化管がん / トランスポーター / 組織差 / P-糖タンパク / radixin |
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| Outline of Final Research Achievements |
Efflux transporters, as exemplified by P-glycoprotein (P-gp), are localized at the plasma membrane and excrete many therapeutic drugs from the cytoplasm to outside the cells. These transporters are therefore known as a major contributing factor resulting in multidrug resistance of cancer cells. Our study indicated that the regulation of transporters by scaffold proteins, such as ezrin, radixin and moesin (ERM proteins) is different between cancerous tissues. Moreover, these regulatory properties are the same as those of the corresponding normal tissues, and suggest that organ-specific differences in the regulation of P-gp by ERM proteins are retained in cancerous tissues. Furthermore, in tissues such as lung cancer, several efflux transporters were controlled by the same one scaffold protein. Therefore, it was suggested that the suppression of a specific scaffold protein comprehensively inactivated efflux transporters in certain kinds of cancerous tissue.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Interaction of Peptide Transporter 1 With d-Glucose and l-Glutamic Acid; Possible Involvement of Taste Receptors.2016
Author(s)
Arakawa H, Ohmachi T, Ichiba K, Kamioka H, Tomono T, Kanagawa M, Idota Y, Hatano Y, Yano K, Morimoto K, Ogihara T.
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Journal Title
J Pharm Sci.
Volume: 105
Issue: 1
Pages: 339-342
DOI
Related Report
Peer Reviewed / Open Access
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