Elucidation of the pathophysiology of psychiatric disorders focused on presynaptic regulation mechanism
| Project/Area Number |
15K08090
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | University of Toyama |
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Principal Investigator |
Miyamoto Yoshiaki 富山大学, 大学院医学薬学研究部(薬学), 准教授 (20449101)
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| Co-Investigator(Renkei-kenkyūsha) |
NITTA Atsumi 富山大学, 大学院医学薬学研究部(薬学), 教授 (20275093)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 精神疾患 / プレシナプスタンパク質 |
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| Outline of Final Research Achievements |
In recent years, patients with psychiatric disorders have been increasing rapidly in Japan. In the present study, we therefore tried to elucidate the etiology and pathophysiology of psychiatric disorder by focusing on the presynaptic protein Piccolo, which has been suggested to be involved in multiple psychiatric disorders in genome-wide association study, in order to develop its therapeutic method.
Neuronal function analysis at the individual, cell and molecular level in the prefrontal cortex Piccolo knockdown mice revealed similar phenotypes to patients with bipolar disorder or schizophrenia. Accordingly, neuronal network impairments from the prefrontal cortex caused emotional disturbance, cognitive dysfunction and stress vulnerability in bipolar disorder or schizophrenia. Furthermore, it was suggested that the genetic manipulation mice are useful as a new psychiatric animal model with high validity.
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Report
(4 results)
Research Products
(56 results)
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[Journal Article] Methamphetamine induces2017
Author(s)
Uno K, Miyazaki T, Sodeyama K, Miyamoto Y, Nitta A.
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Journal Title
PLoS One
Volume: 12
Issue: 3
Pages: e0174196-e0174196
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Decreased DNA methylation in the Shati/Nat8l promoter in both patients with schizophrenia and a methamphetamine-induced murine model of schizophrenia-like phenotype2016
Author(s)
Uno K, Kikuchi Y, Iwata M, Uehara T, Matsuoka T, Sumiyoshi T, Okamoto Y, Jinno H, Takada T, Furukawa-Hibi Y, Nabeshima T, Miyamoto Y, Nitta A
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Journal Title
PLoS One
Volume: 11
Issue: 6
Pages: e0157959-e0157959
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] The piccolo intronic single nucleotide polymorphism rs13438494 regulates dopamine and serotonin uptake and shows associations with dependence-like behavior in genomic association study.2015
Author(s)
Uno K, Nishizawa D, Seo S, Takayama K, Matsumura S, Sakai N, Ohi K, Nabeshima T, Hashimoto R, Ozaki N, Hasegawa J, Sato N, Tanioka F, Sugimura H, Fukuda K, Higuchi S, Ujike H, Inada T, Iwata N, Sora I, Iyo M, Kondo N, Won M-J, Naruse N, Uehara K, Itokawa M, Yamada M, Ikeda K, Miyamoto Y, Nitta A.
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Journal Title
Current molecular medicine
Volume: 15(3)
Issue: 3
Pages: 265-274
DOI
Related Report
Peer Reviewed
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