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Establishment of the social evaluation by the saliva oxytocin measurement

Research Project

Project/Area Number 15K08093
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical pharmacy
Research InstitutionUniversity of Fukui

Principal Investigator

Kosaka Hirotaka  福井大学, 子どものこころの発達研究センター, 教授 (70401966)

Co-Investigator(Kenkyū-buntansha) 齋藤 大輔  金沢大学, 子どものこころの発達研究センター, 特任准教授 (30390701)
藤澤 隆史  福井大学, 子どものこころの発達研究センター, 特命講師 (90434894)
Co-Investigator(Renkei-kenkyūsha) TOMODA Akemi  福井大学, 子どものこころの発達研究センター, 教授 (80244135)
Research Collaborator FUJIOKA Toru  
OKAMOTO Yuko  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsオキシトシン / 社会性 / 唾液濃度
Outline of Final Research Achievements

Although there are some reports measures the peripheral oxytocin levels, the most samples are invasive plasma sample. This way is too difficult for children and individuals with autism spectrum disorders which have hyperesthesia to get blood sampling. The aim of this study is to evaluate saliva oxytocin level as the easily measurement for sociality. We conducted the difference peripheral oxytocin level in plasma and saliva samples using conventional ELISA methods. In addition, we conducted a correlation analysis to investigate relationships between saliva oxytocin levels and percentage fixation time allocated to sociality movies.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (13 results)

All 2018 2017 2016 2015

All Journal Article (10 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 6 results,  Open Access: 6 results,  Acknowledgement Compliant: 4 results) Presentation (3 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Altered perspective-dependent brain activation while viewing hands and associated imitation difficulties in individuals with autism spectrum disorder.2018

    • Author(s)
      Okamoto Y, Kitada R, Miyahara M, Kochiyama T, Naruse H, Sadato N, Okazawa H, Kosaka H.
    • Journal Title

      NeuroImage: Clinical

      Volume: in press. Pages: 384-395

    • DOI

      10.1016/j.nicl.2018.04.030

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 2016年度のASDへのオキシトシン研究から2018

    • Author(s)
      小坂浩隆
    • Journal Title

      発達障害白書 2018年版

      Volume: 2018 Pages: 54-55

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Age-dependent abnormalities in body- and face-sensitive activation of the EBA and FFA in individuals with ASD2017

    • Author(s)
      Okamoto Y, Kosaka H, Kitada R, Seki A, Tanabe HC, Hayashi MJ, Kochiyama T, Saito DN, Yanaka HT, Munesue T, Ishitobi M, Omori M, Wada Y, Okazawa H, Koeda T, Sadato N
    • Journal Title

      Neuroscience Research

      Volume: 印刷中 Pages: 30243-30247

    • DOI

      10.1016/j.neures.2017.02.001

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] オキシトシン治療のこれから2017

    • Author(s)
      小坂浩隆
    • Journal Title

      小児科診療

      Volume: 80 Pages: 843-849

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 自閉スペクトラム症の新しい治療薬の可能性 ~オキシトシン~2016

    • Author(s)
      小坂浩隆、岡本悠子
    • Journal Title

      チャイルドヘルス

      Volume: 19 Pages: 27-32

    • Related Report
      2016 Research-status Report
  • [Journal Article] The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders2016

    • Author(s)
      Okamoto Y, Ishitobi M, Wada Y, Kosaka H.
    • Journal Title

      CNS Neurol Disord Drug Targets

      Volume: 15 Pages: 564-577

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Gazefinder as a clinical supplementary tool for discriminating between autism spectrum disorder and typical development in male adolescents and adults.2016

    • Author(s)
      Fujioka T, Inohara K, Okamoto Y, Masuya Y, Ishitobi M, Saito DN, Jung M, Arai S, Matsumura Y, Fujisawa TX, Narita K, Suzuki K, Tsuchiya JK, Mori N, Katayama T, Sato M, Munesue T, Okazawa H, Tomoda A, Wada Y, Kosaka H.
    • Journal Title

      Molecular Autism

      Volume: 7 Issue: 1 Pages: 19-19

    • DOI

      10.1186/s13229-016-0083-y

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Oxytocin efficacy is modulated by dosage and oxytocin receptor genotype in young adults with high-functioning autism: a 24-week randomized clinical trial.2016

    • Author(s)
      Kosaka H, Okamoto Y, Munesue T, Yamasue H, Inohara K, Fujioka T, Anme T, Orisaka M, Ishitobi M, Jung M, Fujisawa TX, Tanaka S, Arai S, Asano M, Saito DN, Sadato N, Tomoda A, Omori M, Sato M, Okazawa H, Higashida H, Wada Y.
    • Journal Title

      Translational Psychiatry

      Volume: 6 Issue: 8 Pages: e872-e872

    • DOI

      10.1038/tp.2016.152

    • NAID

      120007129377

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Remedial possibility of nasal oxytocin administration for individuals with autism spectrum disorders.2016

    • Author(s)
      Okamoto Y, Ishitobi M, Wada Y, Kosaka H
    • Journal Title

      CNS Neurol Disord Drug Targets

      Volume: 印刷中

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 発達障害の新しい治療法 ~オキシトシンを中心に~2016

    • Author(s)
      小坂浩隆、岡本悠子
    • Journal Title

      チャイルドヘルス

      Volume: 印刷中

    • Related Report
      2015 Research-status Report
  • [Presentation] Attention to eye in still face strongly related to sociality compared to other social information in children with Autism Spectrum Disorder.2018

    • Author(s)
      Toru Fujioka, Yoshifumi Mizuno, Shinichiro Takiguchi, Takashi X. Fujisawa, Kenji J. Tsuchiya, Tiichi Katayama, Akemi Tomoda, Michio Hiratani, Hirotaka Kosaka
    • Organizer
      American Academy of Child and Adolescent Psychiatry’s 64th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Abnormal Regional Neural Function and Functional Integration of the Cerebellum in Children with ADHD: A Resting-State Functional MRI Study.2016

    • Author(s)
      Yoshifumi Mizuno, Minyoung Jung, Takashi Fujisawa, Shinichiro Takiguchi, Koji Shimada, Daisuke Saito, Hirotaka Kosaka, Akemi Tomoda
    • Organizer
      63rd Annual Meeting AACAP
    • Place of Presentation
      New York, USA
    • Year and Date
      2016-10-24
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 自閉スペクトラム症における唾液中/血漿中オキシトシン濃度と社会性の障害との関連 ―視線追跡装置であるGazeFinder®を用いて―2015

    • Author(s)
      松村由紀子、藤岡徹、藤澤隆史、岡本悠子、新井清義、田仲志保、升谷泰裕、石飛信、岡崎玲子、石川俊介、丁ミンヨン、小泉径子、友田明美、小坂 浩隆
    • Organizer
      横浜
    • Place of Presentation
      横浜
    • Year and Date
      2015-09-24
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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