Phathological analysis of RFVT knockout mice

• Project/Area Number: 15K08095
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Kyoto University
• Principal Investigator: Yonezawa Atsushi 京都大学, 薬学研究科, 准教授 (90452341)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ビタミンB2 / トランスポータ / 薬学 / リボフラビン / 薬理学

Outline of Final Research Achievements

Riboflavin (Vitamin B2) is a orange-yellow water-soluble vitamin, which plays important roles in the metabolism of glucose, amino acids and lipids. In the present study, we analyzed the pathology of the disruption in riboflavin transporter RFVT gene. It was revealed that the disruption of RFVT gene induced metabolic disorders, caused by riboflavin deficiency, in mice. These results will contribute to the development of therapy in RFVT-genetic rare diseases.

Research Products

• [Journal Article] Riboflavin Transporters RFVT/SLC52A Mediate Translocation of Riboflavin, Rather than FMN or FAD, across Plasma Membrane (2017)
  • Author(s): Jin Congyun、Yao Yoshiaki、Yonezawa Atsushi、Imai Satoshi、Yoshimatsu Hiroki、Otani Yuki、Omura Tomohiro、Nakagawa Shunsaku、Nakagawa Takayuki、Matsubara Kazuo
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 40 Issue: 11 Pages: 1990-1995
  • DOI: 10.1248/bpb.b17-00292
  • NAID: 130006191824
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed
• [Journal Article] Disruption of Slc52a3 gene causes neonatal lethality with riboflavin deficiency in mice (2016)
  • Author(s): Yoshimatsu H, Yonezawa A, Yamanishi K, Yao Y, Sugano K, Nakagawa S, Imai S, Omura T, Nakagawa T, Yano I, Masuda S, Inui K & Matsubara K
  • Journal Title: Sci Rep Volume: 6 Issue: 1 Pages: 27557-27557
  • DOI: 10.1038/srep27557
  • NAID: 120005818230
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Asymmetric riboflavin distribution in Brown-Vialetto-Van-Laere syndrome patients with SLC52A mutations (2017)
  • Author(s): Atsushi Yonezawa、Kazuo Matsubara
  • Organizer: 10th BioMedical Transporters Conference
  • Int'l Joint Research / Invited