| Project/Area Number |
15K08096
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Shimane University |
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Principal Investigator |
Naora Kohji 島根大学, 医学部, 教授 (90243427)
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| Co-Investigator(Kenkyū-buntansha) |
西村 信弘 島根大学, 医学部, 准教授 (30529657)
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| Research Collaborator |
TAMAKI Hiroki
HONGOH Masafumi
NAKAMURA Takeshi
ISHIHARA Noriyuki
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | PK/PD / tyrosine kinase / inhibitor / チロシンキナーゼ阻害薬 / 慢性骨髄性白血病 / K562細胞 / LC-MS/MS / 血中濃度 / MDR1 / Caspase 3 / PK-PD / 肺癌 / 腎細胞癌 / 耐性 |
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| Outline of Final Research Achievements |
In this study, we investigated factors that alter the pharmacokinetics of tyrosine kinase inhibitor (TKI), a therapeutic agent for oral cancer molecular target. As the results, TKI pharmacokinetics was possibly changed by not only drug interaction of hepatic enzyme induction with rifampicin but also fluid retention by serious renal dysfunction. Therefore, it is necessary to pay attention to fluctuation in the pharmacokinetics, such as blood concentration monitoring of TKI, in the patients with concomitant medications or complications such as renal disorder. In addition, it was shown that prescribed amount of topical moisturizer is an important factor for onset of hand-foot syndrome as major adverse effect of TKI, which suggests the importance of pharmaceutical management for TKI-prescribed patients by pharmacists.
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