| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Pharmacological potency of therapeutic compounds alters in patients with severe disease, in which it is known that besides the affected organ, non-affected organs that are not immediately connected with the disease respond to therapeutic compounds in an altered manner. To clarify mechanism underlying the altered response, we examined the potentiation of the pharmacological effects of sedatives in rats with experimentally induced renal failure. It was demonstrated that the cerebral expression of chloride transporter protein alters with renal failure, suggesting that cellular regulation regarding chloride concentration alters with renal failure to allow the action potential in the nerve cells to be more effectively suppressed.
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