| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The aim of study was to develop novel countermeasures against HIV-1 Env diversity using library for HIV-1 clinical isolates, chemical library for HIV-1 entry inhibitors, and in vitro selection system. We determined that the region of the HIV-1 gp120-gp41 quaternary interface that is a novel target for HIV-1 Env inhibitors. In addition, the Env diversity was decreased within clinical isolates when passaged in the presence of novel inhibitors during in vitro selection. Furthermore, we determined that combination strategies containing entry inhibitors and NAbs are likely to be efficient weapons against HIV-1. These findings can provide useful data to support the design and the development of new HIV-1 entry inhibitors against HIV-1 Env diversity.
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