New diagnostic criteria in early human embryo using computational anatomy and genetic techniques
| Project/Area Number |
15K08134
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
田村 寛 京都大学, 国際高等教育院, 特定教授 (40418760)
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| Research Collaborator |
NAGAI Momoko NHGRI/NIH, 博士研究員 (50755676)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ヒト発生学 / 計算解剖学 / 発生学 / 解剖学 / xxxxxxxx / ヒト胚子 / 核酸抽出 |
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| Outline of Final Research Achievements |
This study includes morphological analyses of three-dimensional images of human fetus by computational anatomy, extraction of genetic data from the specimen, and combination of morphological diagnosis with genetic data. Three-dimensional models was created from MR images for the central nervous system and segmentation of each part of the brain was performed. This data can be applied to Geometric Morphometrics (GM) after landmark setting. In addition, we tried DNA extraction from the old specimens, which are soaked in formalin solution for a long time. It was difficult to obtain extracted DNA capable of carrying out sequence analysis because of denaturation DNA.
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Report
(4 results)
Research Products
(148 results)
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[Journal Article] Quantitation of nasal development in the early prenatal period using geometric morphometrics and MRI: A new insight into the critical period of Binder phenotype.2017
Author(s)
Katsube M, Yamada S, Miyazaki R, Yamaguchi Y, Makishima H, Takakuwa T, Yamamoto A, Fujii Y, Morimoto N, Ito T, Imai H, Suzuki S．
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Journal Title
Prenatal Diag
Volume: 37
Issue: 9
Pages: 907-915
DOI
Related Report
Peer Reviewed
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[Journal Article] Merging and fractionation of muscle synergy indicate the recovery process in patients with hemiplegia: the first study of patients after subacute stroke.2016
Author(s)
Hashiguchi Y, Ohata K, Kitatani R, Yamakami N, Sakuma K, Osako S, Aga Y, Watanabe A, Yamada S.
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Journal Title
Neural Plasticity,
Volume: 2,016
Pages: 5282957-5282957
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Nationwide survey for current clinical status of amniocentesis and maternal serum marker test in Japan.2016
Author(s)
Miyake H, Yamada S, Fujii Y, Sawai H, Arimori N, Yamanouchi Y, Ozasa Y, Kanai M, Sago H, Sekizawa A, Takada F, Masuzaki H, Matsubara Y, Hirahara F, Kugu K.
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Journal Title
J Hum Gen
Volume: 61(10)
Issue: 10
Pages: 879-884
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Presentation] 「The first human embryonic research for the development of the nasal septum using geometric morphometrics: A new insight for the sensitive period for the Binder phenotype.」(Poster)2017
Author(s)
Katsube M, Yamada S, Uwabe C, Makishima H, Miyazaki R, Yamaguchi Y, Ishiyama H, Yamamoto A, Morimoto N, Ito T, Imai H, Matsuda T, Suzuki S.
Organizer
INTERNATIONAL CLEFT CONGRESS 2017Radisson Blu Resort, Temple Bay, Mahabalipuram（Chennai, India）
Place of Presentation
Radisson Blu Resort, Temple Bay, Mahabalipuram（Chennai, India）
Year and Date
2017-02-08
Related Report
Int'l Joint Research
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[Presentation] Relationship between self-perception and social factors in people with Down syndrome(Poster)2017
Author(s)
Miyake H, Yamada S, Fujii Y, Taniguchi-Ikeda M, Urano M, Ozasa Y, Kanai M, Fukushima A, Matsubara Y, Saito K, Konishi I.
Organizer
The 21h International Conference on Prenatal Diagnosis and Therapy
Related Report
Int'l Joint Research
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[Presentation] Trends of genetic prenatal testing in Japan; 1998-2016(Poster)2017
Author(s)
Sasaki A, Sago H, Yoshihash H, Yamada S, Miyake H, Suzumori N, Takada F, Masuzaki H, Hirahara F, Kugu K, Konishi I.
Organizer
The 21h International Conference on Prenatal Diagnosis and Therapy
Related Report
Int'l Joint Research
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[Presentation] Three dimensional utilization of human embryo specimens of the “Kyoto Collection” (Poster)2017
Author(s)
Makishima H, Katsube M, Miyazaki R, Yamaguchi Y, Kobayashi S, Uwabe C, Yamamoto A, Imai H, Yoneyama A, Funatomi T, Morimoto N, Takeda T, Nakatsukasa M, Kose K, Takakuwa T, Yamada S.
Organizer
第50回日本発生生物学会大会
Related Report
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[Presentation] ヒト発生学と先天異常2016
Author(s)
山田重人
Organizer
第12回北関東遺伝診療フォーラム
Place of Presentation
大宮パレスホテル 埼玉県大宮市
Year and Date
2016-11-28
Related Report
Invited
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[Presentation] Current Status of Social Issues for People with Down Syndrome in Japan: From Nationwide Survey.2016
Author(s)
Miyake H, Yamada S, Fujii Y, Taniguchi-Ikeda M, Urano M, Ozasa Y, Kanai M, Fukushima A, Matsubara Y, Saito K, Konishi I.
Organizer
The 13th International Congress of Human Genetics.
Place of Presentation
Kyoto International Conterrence Center,Japan (sakyo-ku kyoto
Year and Date
2016-04-03
Related Report
Int'l Joint Research
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[Presentation] Characteristics of the Genetic Counseling in Kyoto University Hospital to Figure Out the Genetic Counseling Needs in Japan.2016
Author(s)
Matsukawa M, Nishio H, Hiraoka Y, Honda S, Inaba A, Takamine E, Yonei A, Torishima M, Murakami H, Kitajiri S, Wada T, Miyake H, Yamada S, Heike T, Kosugi S.
Organizer
The 13th International Congress of Human Genetics.
Place of Presentation
Kyoto International Conterrence Center,Japan (sakyo-ku kyoto)
Year and Date
2016-04-03
Related Report
Int'l Joint Research
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[Presentation] The current status of conventional prenatal diagnosis in Japan: A Nationwide survey of obstetrics/gynecology facilities.2015
Author(s)
Miyake H, Yamada S, Fujii Y, Sawai H, Arimori N, Yamanuchi Y, Ozasa Y, Kanai M, Sago H, Sekizasa A, Takada F, Masuzaki H, Matsubara Y, Hirahara F, Kugu K
Organizer
21st The International Federation of Gynecology and Obstetrics (FIGO)
Place of Presentation
Vancouver, Canada
Year and Date
2015-10-04
Related Report
Int'l Joint Research
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[Presentation] ヒト発生学と発生学研究2015
Author(s)
山田重人
Organizer
第25回遺伝医学セミナー
Place of Presentation
三井ガーデンホテル（千葉中央区）
Year and Date
2015-09-04
Related Report
Invited
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[Presentation] Survey of conventional prenatal diagnosis in Japan - Nationwide study for obstetricians about prenatal diagnosis2015
Author(s)
Miyake H, Yamada S, Fujii Y, Sawai H, Arimori N, Yamanuchi Y, Ozasa Y, Kanai M, Sago H, Sekizasa A, Takada F, Masuzaki H, Matsubara Y, Hirahara F, Kugu K
Organizer
ISPD 19th International Conference on Prenatal Diagnosis and Therapy
Place of Presentation
Columbia, United States
Year and Date
2015-07-12
Related Report
Int'l Joint Research
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