| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The proepicardial organ (PEO) arises in the sinus venosus region, and then the cells of the PEO spread over the myocardium. These cells differentiate into the epicardium, the fibroblast, the smooth muscle and the endothelial cells of the coronary vessels. The markers of the PEO, such as WT1 and TBX18, were detected in the PEO presumptive region at stage 14. In vitro PEO assay using stage 11-13 showed the reduce of the differentiation into the PEO. When retinoic acid was administrated in the culture medium of the assay, the expression of WT1 and TBX18 protein was increased.
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