| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The hematopoiesis is regulated by stromal cells, as distinguished from hematopoietic cells in hematopoietic microenvironment. In this study, the stromal cells were shown as an essential compartment for regulating the proliferation and differentiation of hematopoietic cells by producing various cytokines and adhesion molecules. Furthermore, stromal cells protected the hematopoietic cells from biological stresses and keep the homeostasis of hematopoietic phenomena. These findings were verified by in vivo and in vitro examinations. The results showed the importance of stromal cells in hematopoietic microenvironment and the qualitative and quantitative impairment of stromal cells may result in the hematopoietic disorders.
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