Histological and functional analysis in the subregion of mammalian circadian center
| Project/Area Number |
15K08163
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
General anatomy (including histology/embryology)
|
|---|
| Research Institution | Kindai University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
長野 護 近畿大学, 医学部, 准教授 (80155960)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
|---|
| Keywords | 視交叉上核 / 概日リズム / 位相波 / Per2 / 短周期領域 / 長周期領域 |
|---|
| Outline of Final Research Achievements |
Mammals have an intrinsic biological clock that shows a stable period of about 24 hours. Underlying this function is the suprachiasmatic nucleus (SCN) in the hypothalamus. We have elucidated that there are cell groups that oscillate rhythms shorter than this period in the dorso-medial region of the SCN (DM-SCN). And we have focused on a phase wave (the expression of the clock gene propagates from medial to lateral SCN) originating from DM-SCN. The presence of spreading of phase wave in the rostro-caudal axis direction in addition to the phase waves towards the lateral sides which was known so far was found by histochemical analysis using the mouse SCN. This result will deepen the basic understanding of the physiologically unknown function of the phase wave.
|
Report
(4 results)
Research Products
(12 results)
