Investigation into neural network of cardiorespiratory interactions

Research Project

Project/Area Number	15K08171
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	General physiology
Research Institution	University of Tsukuba
Principal Investigator	Koganezawa Tadachika 筑波大学, 医学医療系, 助教 (80431691)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	循環調節 / 高血圧 / 交感神経 / 呼吸循環連関 / 循環中枢 / 呼吸中枢
Outline of Final Research Achievements	This project demonstrated that in hypertensive rats, reduction of inspiratory hyperpolarization on the cardiovascular sympathetic premotor neurons (RVLM neurons) enhances respiratory activity of the cardiovascular sympathetic nerve. And, the reduction of inspiratory hyperpolarization on RVLM neurons is caused by activation of excitatory inputs to the RVLM neurons. Moreover, the respiratory modulation into RVLM neurons in eupnea is maintained by endogenous hydrogen sulfide which is produced by hydrogen sulfide synthase.