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Roles for microglial calcium channels in neurodegenerative diseases

Research Project

Project/Area Number 15K08172
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General physiology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

SAEGUSA Hironao  東京医科歯科大学, 大学院医歯学総合研究科, 助教 (90261205)

Research Collaborator HUNTULA Soontaraporn  
WANG Xinshuang  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
KeywordsCaチャネル / Cav1.2 / Cav2.2 / パーキンソン病 / MPTP / ミクログリア / 電位依存性Caチャネル / 神経変性疾患
Outline of Final Research Achievements

Voltage-dependent calcium channel (VDCC) has been thought to play important roles in excitatory cells such as neurons. However, we have recently clarified that N-type VDCC in microglia, a non-excitatory cell type, is also critically involved in development of neuropathic pain, an intractable pain caused by nerve injuries. In the present study, we have addressed a question whether the microglial VDCCs are also involved in pathophysiology of neurodegenerative diseases. By using cultured microglial cells and transgenic mice, where knock down of microglial VDCC is achieved, we have found the following results. Knocking down the microglial N-type VDCC lead to ameliorating neurological symptoms and on the other hand knocking down L-type VDCC results in exaggeration of the symptoms. Therefore, microglial VDCCs are actually involved in the pathophysiology of neurodegenerative diseases as well but the mechanism underlying is yet to be clarified.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (3 results)

All 2018 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Remarks (2 results)

  • [Journal Article] Involvement of phosphatidylinositol-3 kinase/Akt/mammalian target of rapamycin/peroxisome proliferator-activated receptor γ pathway for induction and maintenance of neuropathic pain2018

    • Author(s)
      Kondo Daisuke、Saegusa Hironao、Tanabe Tsutomu
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 499 Issue: 2 Pages: 253-259

    • DOI

      10.1016/j.bbrc.2018.03.139

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Remarks] 東京医科歯科大学大学院 認知行動医学講座 細胞薬理学分野

    • URL

      http://www.tmd.ac.jp/med/mphm/Yakuri.HTM

    • Related Report
      2017 Annual Research Report
  • [Remarks] 東京医科歯科大学大学院医歯学総合研究科細胞薬理学分野ホームページ

    • URL

      http://www.tmd.ac.jp/med/mphm/Yakuri.HTM

    • Related Report
      2016 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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