| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
Voltage-gated proton channel, Hv1/VSOP, has a role to regulate neutrophil function and inhibit an inflammation in pathogen infection. Hv1/VSOP-deficient mice exhibit excess inflammation in lung after Candida infection. In this study, we found that Hv1/VSOP negatively regulates ROS production in neutrophils stimulated with low concentrations of fMLF. And, we demonstrated that this inhibitory function by Hv1/VSOP in ROS production is necessary for inhibiting ERK-dependent chemotactic response to low fMLF concentrations. These results may suggest that Hv1/VSOP inhibits an inflammation by suppressing neutrophil migration to infection site upon pathogen infection.
|
