Elucidation of the mechanism of sinus node dysfunction occurrence in diabetes

• Project/Area Number: 15K08180
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General physiology
• Research Institution: Oita University
• Principal Investigator: SHINOHARA TETSUJI 大分大学, 医学部, 助教 (60457629)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 糖尿病 / 心房細動 / レプチン / 洞結節機能 / 心筋線維化 / 肥満 / 酸化ストレス

Outline of Final Research Achievements

The patients with diabetes often causes rhythm abnormalities such as sick sinus syndrome and atrial fibrillation. It is considered that the involvement of sinus node cell fibrosis and remodeling. The present study suggests that mast cells contribute to the pathogenesis of hyperglycemia-induced atrial fibrillation via enhancement of inflammation and fibrosis　(Uemura K, Shinohara T, et al. J Cardiovasc Electrophysiol. 2016;27:981-9). Furthermore, we reported that hyperleptinemia induces high-fat diet-mediated atrial fibrosis and fibrillation (Fukui A, Shinohara T, et al. J Cardiovasc Electrophysiol. 2017;28:702-710). In addition, we demonstrated that interleukin 10 can inhibit atrial remodeling and atrial fibrillation caused by a high-fat-diet.

Research Products

• [Journal Article] Hyperleptinemia Exacerbates High-Fat Diet-Mediated Atrial Fibrosis and Fibrillation. (2017)
  • Author(s): Fukui A, Ikebe-Ebata Y, Kondo H, Saito S, Aoki K, Fukunaga N, Shinohara T, Masaki T, Teshima Y, Takahashi N.
  • Journal Title: J Cardiovasc Electrophysiol. Volume: 印刷中 Issue: 6 Pages: 702-710
  • DOI: 10.1111/jce.13200
  • Peer Reviewed / Open Access
• [Journal Article] Mast Cells Play an Important Role in the Pathogenesis of Hyperglycemia-Induced Atrial Fibrillation (2016)
  • Author(s): Uemura K, Kondo H, Ishii Y, Kobukata M, Haraguchi M, Imamura T, Otsubo T, Ikebe-Ebata Y, Abe I, Ayabe R, Saito S, Aoki K, Nagano-Torigoe Y, Akioka H, Shinohara T, Teshima Y, Masaki T, Yufu K, Nakagawa M, Takahashi N
  • Journal Title: J Cardiovasc Electrophysiol Volume: - Issue: 8 Pages: 981-989
  • DOI: 10.1111/jce.12995
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Cardiac sympatho-vagal imbalance in patients with symptomatic J wave syndrome: Results of cardiac MIBG scintigraphic findings and baroreflex sensitivity (2016)
  • Author(s): Tetsuji Shinohara
  • Organizer: TTS conference
  • Place of Presentation: Sapporo Convention Center Hokkaido Sapporo city
  • Year and Date: 2016-07-16
  • Int'l Joint Research / Invited
• [Presentation] Effect of baroreflex sensitivity on the incidence of ventricular fibrillation in patients with Brugada syndrome (2016)
  • Author(s): Tetsuji Shinohara, Hidekazu Kondo, Toyokazu Ootsubo, Akioka, Kunio Yufu, Mikiko Nakagawa, Naohiko Takahashi
  • Organizer: 第63回日本不整脈心電学会学術大会
  • Place of Presentation: 札幌コンベンションセンター 北海道 札幌市
  • Year and Date: 2016-07-14
• [Presentation] An exaggerated vagal nerve activity is involved in the recurrence of ventricular fibrillation related to J-wave syndrome (2016)
  • Author(s): Shinohara T,Kondo H,Otsubo T,Ishii Y,Kobukata M,Haraguchi M,Yoshida M,Saito S,Ayabe R,Nagano Y,Akioka H,Teshima Y,yufu K
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター（宮城県，仙台市）
  • Year and Date: 2016-03-18