Involvement of Chemosensory System on Intestinal Epithelial Function
| Project/Area Number |
15K08182
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Kyoto Prefectural University of Medicine (2017)
University of Shizuoka (2015-2016) |
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Principal Investigator |
Kuwahara Atsukazu 京都府立医科大学, 医学(系)研究科(研究院), 特任教授 (60142890)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | chemosensory cell / enteroendocrine cell / epithelial ion transport / enteric nervous ssytem / brain-gut axis / 腸内分泌細胞 / 脳腸相関 / 散在性化学物質受容機構 / エネルギー制御 / 腸内細菌 / 恒常性維持機構 / 高次脳機能 / メタボリックシンドローム / 散在性化学受容機構 / ネルギー制御 |
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| Outline of Final Research Achievements |
The intestinal lumen is open to the external environment and GI tract is one-way tube in which food materials are progressively converted into molecular end products. Recently, the taste receptors, along with several taste signal transduction molecules, have been demonstrated to be expressed in many extraoral location. In the GI tract, nutrients and microbial metabolites are continuously sensed by chemosensory receptors which are analog of taste receptors in the tongue. Chemosensory receptor expressing cells in the GI tract is belonging to a part of diffuse chemosensory system (DCS). In the GI tract, DCS consists of enteroendocrine and related cells. These cells initiate various important local and remote reflexes. Despite obvious physiological and clinical importance, not enough information is available regarding the function of DCS in the GI tract. In this research project, we have examined the contribution of DCS on intestinal epithelial ion transport.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Neural FFA3 activation inversely regulates anion secretion evoked by nicotinic ACh receptor activation in rat proximal colon.2016
Author(s)
Kaji, I.;Akiba, Y.;Konno, K.;Watanabe, M.;Kimura, S.;Iwanaga, T.;Kuri, A.;Iwamoto, K. I.;Kuwahara, A.;Kaunitz, J. D.
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Journal Title
J Physiol
Volume: －
Issue: 12
Pages: 3339-3352
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Activation of muscarinic cholinoceptor ameliorates tumor necrosis factor-a-induced barrier dysfunction in intestinal epithelial cells.2015
Author(s)
Khan MR, Uwada J, Yazawa T, Islam MT, Krug SM, Fromm M, Karaki S, Suzuki Y, Kuwahara A, Yoshiki H, Sada K, Muramatsu I, Anisuzzaman AS and Taniguchi T.
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Journal Title
FEBS Lett.
Volume: 589
Issue: 23
Pages: 3640-3647
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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