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Can cilia of ventricular ependymal cells control flow of CSF?

Research Project

Project/Area Number 15K08185
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General physiology
Research InstitutionDokkyo Medical University

Principal Investigator

SEO Yoshiteru  獨協医科大学, 医学部, 教授 (90179317)

Co-Investigator(Kenkyū-buntansha) 竹井 元  獨協医科大学, 医学部, 助教 (00708183)
Research Collaborator NAKAHARI takashi  
WAKASHIN hidefumi  
SEO eriko  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords脳脊髄液 / 水頭症 / 線毛運動 / 鰓線毛 / ムラサキイガイ / ビデオマイクロスコピー / MRI / 赤外プレチスモグラフィー / MRI
Outline of Final Research Achievements

In order to analyse hydrodynamics of cerebrospinal fluid in the hydrocephalus, contribution of cilia of ventricular ependymal cells was focused. Cilia of gills of bivalves were selected as a model system. Microscopic motion of cilia was observed by videomicroscopy, and the macroscopic water flow in the mantle was analysed by MRI. We found some discrepancy between the microscopic and macroscopic water movements, and this result suggested usefulness of the bivalves as a model system for the future study.

Academic Significance and Societal Importance of the Research Achievements

脳室上衣細胞線毛の運動性の低下したマウスが水頭症を発症することから、脳脊髄液の流れが線毛運動により制御されていると推察されている。しかし、哺乳動物の脳室内の線毛運動と流れを測定することは事実上不可能である。ビデオマイクロスコピーとMRIを用いた本研究によって、二枚貝の鰓線毛と外套膜腔の水流剛体の解析が可能となる事が示された。二枚貝は実験動物への倫理的障壁も低く、良いモデルシステムとして水頭症の病因究明に貢献しうる。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (8 results)

All 2018 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (6 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results)

  • [Journal Article] Accumulation and excretion of manganese ion in the kidney of Mytilus galloprovincialis2018

    • Author(s)
      Wakashin Hidefumi、Seo Eriko、Seo Yoshiteru
    • Journal Title

      The Journal of Experimental Biology

      Volume: 221

    • DOI

      10.1242/jeb.185439

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A portable infrared photoplethysmograph: Heartbeat of Mytilus galloprovincialis analyzed by MRI and application to Bathymodiolus septemdierum.2016

    • Author(s)
      Seo E, Sazi T, Togawa M, Nagata O, Murakami M, Kojima S, Seo Y
    • Journal Title

      Biol Open

      Volume: 5 Issue: 11 Pages: 1752-1757

    • DOI

      10.1242/bio.020909

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Accumulation of Mn2+ by kidney of bivalve2018

    • Author(s)
      Y Seo, H Wakashin, E Seo
    • Organizer
      95th Annual Meeting of the Physiological Society of Japan
    • Related Report
      2017 Research-status Report
  • [Presentation] Heart rate measurement by T1w-MRI and infrared photoplethysmography of Mytilus galloprovincialis.2016

    • Author(s)
      Y Seo, T Sazi, M Togawa, O Nagata, M Yokoi-Hayakawa, Y Imaizumi-Ohashi, M Murakami
    • Organizer
      44th Annual Meeting of Japanese Society of Magnetic Resonance in Medicine
    • Place of Presentation
      大宮ソニックシティ(埼玉県大宮市)
    • Year and Date
      2016-09-09
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Noninvasive Analysis of Cardiovascular Function of Deep-sea Bivalves by 7 T MRI2016

    • Author(s)
      Y Seo, E Seo, T Ikuta, T Maruyama, S Kojima
    • Organizer
      27th International Conference of Magnetic Resonance in Biological Ststems
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2016-08-21
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Noninvasive analysis of cardiac function of inside shells by using MRI and photoplethysmography2016

    • Author(s)
      Yoshiteru Seo
    • Organizer
      93rd Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      札幌コンベンションセンター、札幌
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] Visualization of water flow in mantle cavity of bivalves by 7 T MRI2015

    • Author(s)
      Yoshiteru Seo
    • Organizer
      13th International Conference on Magnetic Resonance Microscopy
    • Place of Presentation
      Technische Universitat Munchen, Germany
    • Year and Date
      2015-08-06
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 二枚貝鰓水流の動態: Mytilus is not a boring black shell2015

    • Author(s)
      瀬尾 芳輝
    • Organizer
      第55回海中海底工学フォーラム
    • Place of Presentation
      東京大学、東京
    • Year and Date
      2015-04-10
    • Related Report
      2015 Research-status Report
    • Invited

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Published: 2015-04-16   Modified: 2020-03-30  

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