Biomarkers of cardiac fibrosis in pressure overloaded heart.
| Project/Area Number |
15K08190
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
南沢 享 東京慈恵会医科大学, 医学部, 教授 (40257332)
岩本 武夫 東京慈恵会医科大学, 医学部, 准教授 (90568891)
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| Research Collaborator |
KUGA Kazuhiro
YAMADA Yuki
USUI Fumio
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 線維化 / 圧負荷 / 心臓線維化 / 心臓肥大 / バイオマーカー |
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| Outline of Final Research Achievements |
We found that the expression level of FGF23 in cardiac hyptrophy with fibrosis was significantly stronger than that of cardiac hypertrophy without fibrosis. To investigate whether FGF23 was a key factor of cardiac fibrosis, we applied FGF23 on cardiac fibroblast. FGF23 did not show any changes. However, FGF23 tended to promote trans-differentiation of fibroblasts stimulated by TGF-β
These results indicate that FGF23 is identified as a novel fibrosis-related gene and may enhance the effect of cytokines (ex TGF-beta) in initiation of cardiac fibrosis.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Tissue thrombin is associated with the pathogenesis of dilated cardiomyopathy.2016
Author(s)
Ito K, Hongo K, Date T, Ikegami M, Hano H, Owada M, Morimoto S, Kashiwagi Y, Katoh D, Yoshino T, Yoshii A, Kimura H, Nagoshi T, Kajimura I, Kusakari Y, Akaike T, Minamisawa S, Ogawa K, Minai K, Ogawa T, Kawai M, Yajima J, Matsuo S, Yamane T, Taniguchi I, Morimoto S, Yoshimura M.
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Journal Title
Int J Cardiol.
Volume: 228
Pages: 821-827
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Low Cardiac Output Leads Hepatic Fibrosis in Right Heart Failure Model Rats.2016
Author(s)
Fujimoto Y, Urashima T, Shimura D, Ito R, Kawachi S, Kajimura I, Akaike T, Kusakari Y, Fujiwara M, Ogawa K, Goda N, Ida H, Minamisawa S
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Journal Title
PLoS One
Volume: 11(2)
Issue: 2
Pages: e0148666-e0148666
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Heterozygous deletion of sarcolipin maintains normal cardiac function.2015
Author(s)
Shimura D, Kusakari Y, Sasano T, Nakashima Y, Nakai G, Jiao Q, Jin M, Yokota T, Ishikawa Y, Nakano A, Goda N, Minamisawa S.
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Journal Title
Am J Physiol Heart Circ Physiol.
Volume: 310(1)
Issue: 1
Pages: 92-103
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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