Elucidation of activation mechanism for osmo-sensitive TRP channel and its physiological role
| Project/Area Number | 15K08197 |
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
General physiology
|
|---|
| Research Institution | Fukuoka University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed(Fiscal Year 2017)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost : ¥3,700,000、Indirect Cost : ¥1,110,000)
Fiscal Year 2017 : ¥1,820,000 (Direct Cost : ¥1,400,000、Indirect Cost : ¥420,000)
Fiscal Year 2016 : ¥1,170,000 (Direct Cost : ¥900,000、Indirect Cost : ¥270,000)
Fiscal Year 2015 : ¥1,820,000 (Direct Cost : ¥1,400,000、Indirect Cost : ¥420,000)
|
|---|
| Keywords | 機械刺激 / TRP / 細胞容積調節 / 浸透圧 / イオンチャネル / 細胞死 / パッチクランプ / クロライドイオン / TRPM2 / TRPM7 / 脂質 / 温度 |
|---|
| Outline of Final Research Achievements |
The elucidation of the mechanism of activation of ion channels activated by osmotic stimulation is not well understood in cell volume regulation and in vivo physiological role. Therefore, we aimed at a comprehensive understanding of the activation mechanism and physiological role of each ion channel from the molecular level to the organization and individual level in multiple levels. As a result of the research, we have reported the activation mechanism of PKD2L1, a causative gene of polycystic kidney disease, and clarified the activation mechanisms of TRP channel (TRPV1, M2, M4, A1) and physiological role in vivo. We also report on the mechanism of water secretion of chloride channel activated by osmotic pressure change.
|
Report
(4results)
Research Products
(51results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] TRPM2 channels in alveolar epithelial cells mediate bleomycin-induced lung inflammation2016
Author(s)
Yonezawa R, Yamamoto S, Takenaka M, Kage Y, Negoro T, Toda T, Ohbayashi M, Numata T, Nakano Y, Yamamoto T, Mori Y, Ishii M, Shimizu S
-
Journal Title
Free Radic Biol Med
Volume : 90
Pages : 101-113
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
-
-
-
-
-
[Journal Article] Compromised maturation of GABAergic inhibition underlies abnormal network activity in the hippocampus of epileptic Ca2+ channel mutant mice, tottering.2015
Author(s)
Nakao A, Miki T, Shimono K, Oka H, Numata T, Kiyonaka S, Matsushita K, Ogura H, Niidome T, Noebels JL, Wakamori M, Imoto K, Mori Y
-
Journal Title
Pflugers Arch
Volume : 467
Pages : 737-752
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
