Elucidation of activation mechanism for osmo-sensitive TRP channel and its physiological role
| Project/Area Number | 15K08197 |
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed(Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost : ¥3,700,000、Indirect Cost : ¥1,110,000)
Fiscal Year 2017 : ¥1,820,000 (Direct Cost : ¥1,400,000、Indirect Cost : ¥420,000)
Fiscal Year 2016 : ¥1,170,000 (Direct Cost : ¥900,000、Indirect Cost : ¥270,000)
Fiscal Year 2015 : ¥1,820,000 (Direct Cost : ¥1,400,000、Indirect Cost : ¥420,000)
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| Keywords | 機械刺激 / TRP / 細胞容積調節 / 浸透圧 / イオンチャネル / 細胞死 / パッチクランプ / クロライドイオン / TRPM2 / TRPM7 / 脂質 / 温度 |
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| Outline of Final Research Achievements |
The elucidation of the mechanism of activation of ion channels activated by osmotic stimulation is not well understood in cell volume regulation and in vivo physiological role. Therefore, we aimed at a comprehensive understanding of the activation mechanism and physiological role of each ion channel from the molecular level to the organization and individual level in multiple levels. As a result of the research, we have reported the activation mechanism of PKD2L1, a causative gene of polycystic kidney disease, and clarified the activation mechanisms of TRP channel (TRPV1, M2, M4, A1) and physiological role in vivo. We also report on the mechanism of water secretion of chloride channel activated by osmotic pressure change.
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Report
(4results)
Research Products
(51results)
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[Journal Article] Optical control of neuronal firing via photoinduced electron transfer in donor–acceptor conjugates2016
Author(s)
Yuta Takano, Tomohiro Numata, Kazuto Fujishima, Kazuaki Miyake, Kazuya Nakao, Wesley David Grove, Ryuji Inou, Mineko Kengaku, Shigeyoshi Sakaki, Yasuo Mori, Tatsuya Murakami and Hiroshi Imahori
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Journal Title
Chem. Sci.
Volume : n.d.
Pages : 3331-3337
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Ablation of the N-type calcium channel ameliorates diabetic nephropathy with improved glycemic control and reduced blood pressure.2016
Author(s)
Ohno S, Yokoi H, Mori K, Kasahara M, Kuwahara K, Fujikura J, Naito M, Kuwabara T, Imamaki H, Ishii A, Saleem MA, Numata T, Mori Y, Nakao K, Yanagita M, Mukoyama M
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Journal Title
Sci Rep.
Volume : 6
Pages : 27192-27192
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS.2016
Author(s)
Miyake T, Nakamura S, Zhao M, So K, Inoue K, Numata T, Takahashi N, Shirakawa H, Mori Y, Nakagawa T, Kaneko S
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Journal Title
Nature communications
Volume : 7
Pages : 12840-12840
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] TRPM2 channels in alveolar epithelial cells mediate bleomycin-induced lung inflammation2016
Author(s)
Yonezawa R, Yamamoto S, Takenaka M, Kage Y, Negoro T, Toda T, Ohbayashi M, Numata T, Nakano Y, Yamamoto T, Mori Y, Ishii M, Shimizu S
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Journal Title
Free Radic Biol Med
Volume : 90
Pages : 101-113
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Compromised maturation of GABAergic inhibition underlies abnormal network activity in the hippocampus of epileptic Ca2+ channel mutant mice, tottering.2015
Author(s)
Nakao A, Miki T, Shimono K, Oka H, Numata T, Kiyonaka S, Matsushita K, Ogura H, Niidome T, Noebels JL, Wakamori M, Imoto K, Mori Y
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Journal Title
Pflugers Arch
Volume : 467
Pages : 737-752
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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