• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Novel mechanism for energy metabolism regulated by a Ca2+-sensor protein

Research Project

Project/Area Number 15K08200
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General physiology
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

Nishitani Tomoe  国立研究開発法人国立循環器病研究センター, 研究所, 室長 (50393244)

Co-Investigator(Kenkyū-buntansha) 中川 修  国立研究開発法人国立循環器病研究センター, 研究所, 部長 (40283593)
Co-Investigator(Renkei-kenkyūsha) WAKABAYASHI Shigeo  大阪医科大学, 生命科学講座薬理学, 非常勤講師 (70158583)
NAKAO Shu  立命館大学, 生命科学部生命医科学科, 助教 (30646956)
Research Collaborator KAWAKAMI Haruka  国立研究開発法人国立循環器病研究センター, 研究所, 研究補助員
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsカルシウム / 代謝異常 / ミトコンドリア / 肥満 / 代謝疾患 / メタボローム解析 / 肥満制御 / カルシムシグナル / ミトコンドリア呼吸 / カルシウムセンサー / 代謝
Outline of Final Research Achievements

Obesity is a leading cause of life-threatening diseases, thus clarifying its molecular mechanism is important. We have previously reported that mice lacking a Ca2+ sensor protein NCS-1(NCS1-/-) exhibited significant obesity. Using metabolic cages, we found that food intake and locomotor activity were similar between the two groups. However, energy metabolism (i.e. O2 consumption/CO2 emission) were significantly lower in NCS1-/- mice. In the cellular level, indicators for mitochondrial function and number (respiratory rate, and the levels of UCP1, PGC-1α) were also decreased. Metabolome analyses demonstrated that the metabolites involved in energy consumption were decreased whereas those in energy storage were increased, leading to massive obesity. Taken together, these results suggest that NCS-1 is a novel regulator of energy metabolism in adipocytes, and hence can be an important target for treatment of metabolic syndrome.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (16 results)

All 2017 2016 2015

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (12 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results)

  • [Journal Article] Possible Signaling Pathways Mediating Neuronal Calcium Sensor-1-Dependent Spatial Learning and Memory in Mice2017

    • Author(s)
      Tomoe Y Nakamura, Shu Nakao, Yukako Nakajo, Jun C Takahashi, Shigeo Wakabayashi, Hiroji Yanamoto
    • Journal Title

      PloS one

      Volume: 12 Issue: 1 Pages: 1-1

    • DOI

      10.1371/journal.pone.0170829

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neuronal Ca 2+ sensor-1 contributes to stress tolerance in cardiomyocytes via activation of mitochondrial detoxification pathways2016

    • Author(s)
      Tomoe Y Nakamura, Shu Nakao, Shigeo Wakabayashi
    • Journal Title

      Journal of molecular and cellular cardiology

      Volume: 99 Pages: 23-34

    • DOI

      10.1016/j.yjmcc.2016.08.013

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Calcineurin B homologous protein 3 negatively regulates cardiomyocyte hypertrophy via inhibition of glycogen synthase kinase 3 phosphorylation.2015

    • Author(s)
      1.Soushi Kobayashi, Tomoe Y. Nakamura, Shigeo Wakabayashi.
    • Journal Title

      J. Mol. Cell. Cardiol.

      Volume: 未定 Pages: 133-42

    • DOI

      10.1016/j.yjmcc.2015.04.018

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Stimulus-dependent regulation of nuclear Ca2+ signaling in cardiomyocytes: a role of neuronal calcium sensor-12015

    • Author(s)
      2.Shu Nakao, Shigeo Wakabayashi, Tomoe Y. Nakamura. Stimulus-dependent regulation of nuclear Ca2+ signaling in cardiomyocytes: a role of neuronal calc
    • Journal Title

      PLoS ONE

      Volume: 10 Issue: 4 Pages: e0125050-e0125050

    • DOI

      10.1371/journal.pone.0125050

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Novel mechanism of stress tolerance of cardiomyocytes mediated by a Ca2+ sensor protein NCS-12017

    • Author(s)
      Tomoe Y. Nakamura, Shu Nakao, Shigeo Wakabayashi
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] 心筋に高発現するCHP3はAkt/GSK3βシグナルを介して心筋細胞肥大を抑制する2017

    • Author(s)
      古林 創史、西谷友重、金美花、若林繁夫
    • Organizer
      近畿生理談話会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Hey1 expression in pharyngeal arch and presomitic mesoderm is regulated by a distal enhancer2017

    • Author(s)
      渡邉裕介、石井修平、深山俊治、上本泰生、井原大、西谷友重、荒井勇二、中川修
    • Organizer
      ConBIO2017, 2017年度生命科学系学会合同年次大会, 第40回日本分子生物学会年会, 第90回日本生化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Role of NCS-1 in cardiovascular and neuronal tissues2016

    • Author(s)
      Tomoe Y. Nakamura
    • Organizer
      Neuronal CalciumSensors in Health and Disease
    • Place of Presentation
      Hanse-Wissenschaftskolleg Institute for Advanced Study, Germany
    • Year and Date
      2016-12-05
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 細胞内Ca2+センサーによるミトコンドリア機能制御と心筋ストレス防御2016

    • Author(s)
      西谷(中村)友重、若林繁夫、中川修
    • Organizer
      第26回日本循環薬理学会
    • Place of Presentation
      信州大学医学部
    • Year and Date
      2016-12-02
    • Related Report
      2016 Research-status Report
  • [Presentation] マウスの空間学習・記憶におけるカルシウムセンサーNCS-1の役割とシグナル伝達経路2016

    • Author(s)
      中村(西谷)友重、中尾 周、中城有香子、若林繁夫、柳本広二
    • Organizer
      第109回 近畿生理学談話会
    • Place of Presentation
      大阪市立大学医学部
    • Year and Date
      2016-11-05
    • Related Report
      2016 Research-status Report
  • [Presentation] 心筋細胞における核内Ca2+濃度制御機構とCa2+センサーNCS-1の役割2016

    • Author(s)
      西谷(中村)友重、中尾周、若林繁夫
    • Organizer
      生理学研究所 研究会2016
    • Place of Presentation
      九州大学
    • Year and Date
      2016-10-24
    • Related Report
      2016 Research-status Report
  • [Presentation] Divergent roles of neuronal Ca2+ sensor-1 in immature and diseased hearts2016

    • Author(s)
      Tomoe Y. Nakamura-Nishitani1, Shu Nakao, and Shigeo Wakabayashi
    • Organizer
      医工連携国際シンポジウム2016
    • Place of Presentation
      東京医科歯科大学
    • Year and Date
      2016-07-11
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 継続的な有酸素運動はCa2+センサー蛋白質欠損で起こるマウスの肥満を解消できる2015

    • Author(s)
      若林繁夫、中尾周、稲垣薫克、土持裕胤、中村―西谷友重、白井幹康
    • Organizer
      第38回日本分子生物学会年会および第88回日本生化学会大会 合同大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] 細胞内Ca2+センサーによる新規代謝調節経路2015

    • Author(s)
      西谷(中村)友重、中尾周、中川修、若林繁夫
    • Organizer
      第88回日本生化学会大会 合同大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] 細胞内カルシウムセンサーによる心筋ストレス防御機構2015

    • Author(s)
      西谷(中村)友重、中尾周、若林繁夫
    • Organizer
      心血管膜輸送研究会2015
    • Place of Presentation
      生理学研究所
    • Year and Date
      2015-10-29
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 細胞内Ca2+センサー蛋白質を介した心筋内ストレス防御機構2015

    • Author(s)
      西谷(中村)友重、中尾周、若林繁夫
    • Organizer
      第108回 近畿生理談話会
    • Place of Presentation
      近畿大学
    • Year and Date
      2015-10-24
    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi