Clarification of action of estrogen to regulate cardiovascular function: Validation of involvement of oxytocin and vitamin D

Research Project

Project/Area Number	15K08203
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Environmental physiology(including physical medicine and nutritional physiology)
Research Institution	University of Fukui
Principal Investigator	Murata Takuya 福井大学, ライフサイエンス支援センター, 准教授 (70281186)
Co-Investigator(Kenkyū-buntansha)	松岡達福井大学, 学術研究院医学系部門, 教授 (00263096) 成田和巳福井大学, 学術研究院医学系部門, 助教 (80270958)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords	エストロジェン / オキシトシン / ビタミンD / 心機能 / ラット / ビタミンＤ / 心筋
Outline of Final Research Achievements	The aim of this study was to clarify the roles of oxytocin (OT) and vitamin D (VD) in regulation of the cardiovascular system by estrogen. Suppression of expression of the VD receptor (VDR) in murine atrial cardiomyocyte-derived cells resulted in Ca transient abnormalities and decreased the expression of several genes involved in the cardiac function. In the proestrus of rats, blood pressure decreased and mRNA expression of the aortic OT receptor (OTR) increased. Furthermore, mRNA expression of VDR in the right atrium of ovariectomized female rats was suppressed by estrogen administration. These findings suggest that OT and VD have complementary roles to promote regulation of the cardiovascular system by estrogen.