| Project/Area Number |
15K08217
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Toho University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Hattori Mitsuru 東京大学, 理学系研究科, 特任研究員 (20589858)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | circadian rhythm / clock gene / phosphorylation / p53 / Bioluminescence / heat shock / stress response / UV / transcription factor / biological clock / protein kinase / enzyme |
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| Outline of Final Research Achievements |
Disorder of biological clocks cause /exacerbate lifestyle-related diseases and cancers. Daily oscillating circadian adaptation system (CAS) with synchronizing ability to environments, based on molecular clocks with clock genes, e.g., Bmal1, integrate timings of various physiological functions in whole body, and to coordinate anti-diseases adaptation systems. In this study, I first elucidated oscillatory mechanism for circadian phosphorylation of BMAL1 clock protein, the core of protein modification /binding oscillators to drive CAS. Additionally, I investigated behavior and structural basis for time-dependent crosstalk by networking among transcription factors BMAL1, heat-shock responsive HSF1 and tumor-suppressor p53 during UV-triggered clock synchronization, to elucidate activation mechanism of CAS in response to cell stresses. The achievements lead to novel medicine targeted to CAS.
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