Muscle and bone network system induced by mechanical factors

• Project/Area Number: 15K08220
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: Kindai University
• Principal Investigator: KAJI Hiroshi 近畿大学, 医学部, 教授 (90346255)
• Co-Investigator(Kenkyū-buntansha): 河尾 直之 近畿大学, 医学部, 講師 (70388510)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 骨格筋 / 骨 / メカニカルストレス / 重力 / 前庭系 / フォリスタチン / 骨粗鬆症 / アイリシン / 前庭 / 筋 / マイオスタチン / ビタミンD / 前庭神経

Outline of Final Research Achievements

The interactions between skeletal muscle and bone (muscle/bone relationships) have been recently noted. We investigated the influences of mechanical factors on muscle/bone relationships using the comprehensive gene analysis in mice. Our studies indicated the following conclusions: 1. Gravity change affects muscle and bone volume through the vestibular system. 2. Follistatin is involved in the effects of gravity change on muscle and bone as a humoral factor from muscle tissues. 3. Mechanical stress increases bone mineral density through the enhancement of irisin production from muscle.

Research Products

• [Journal Article] Role of follistatin in muscle and bone alterations induced by gravity change in mice. (2018)
  • Author(s): Kawao N, Morita H, Obata K, Tatsumi K, Kaji H.
  • Journal Title: J Cell Physiol. Volume: 233 Issue: 2 Pages: 1191-1201
  • DOI: 10.1002/jcp.25986
  • Peer Reviewed
• [Journal Article] Roles of irisin in the linkage from muscle to bone during mechanical unloading in mice (2018)
  • Author(s): Kawao N, Moritake A, Tatsumi K, Kaji H
  • Journal Title: Calcified Tissue International Volume: － Issue: 1 Pages: 24-34
  • DOI: 10.1007/s00223-018-0387-3
  • Peer Reviewed / Open Access
• [Journal Article] Role of Macrophages and Plasminogen Activator Inhibitor-1 in Delayed Bone Repair in Diabetic Female Mice (2018)
  • Author(s): Shimoide Takeshi、Kawao Naoyuki、Tamura Yukinori、Okada Kiyotaka、Horiuchi Yoshitaka、Okumoto Katsumi、Kurashimo Shinji、Ishida Masayoshi、Tatsumi Kohei、Matsuo Osamu、Kaji Hiroshi
  • Journal Title: Endocrinology Volume: 159 Issue: 4 Pages: 1875-1885
  • DOI: 10.1210/en.2018-00085
  • Peer Reviewed / Open Access
• [Journal Article] Effects of hypergravity on gene levels in anti-gravity muscle and bone through the vestibular system in mice. (2017)
  • Author(s): Kawao N, Morita H, Nishida K, Obata K, Tatsumi K, Kaji H.
  • Journal Title: J Physiol Sci. Volume: － Issue: 5 Pages: 609-616
  • DOI: 10.1007/s12576-017-0566-4
  • NAID: 40021645358
  • Peer Reviewed
• [Journal Article] Plasminogen activator inhibitor-1 deficiency enhances subchondral osteopenia after induction of osteoarthritis in mice. (2017)
  • Author(s): Moritake A, Kawao N, Okada K, Tatsumi K, Ishida M, Okumoto K, Matsuo O, Akagi M, Kaji H.
  • Journal Title: BMC Musculoskelet Disord. Volume: 18 Issue: 1 Pages: 392-392
  • DOI: 10.1186/s12891-017-1752-5
  • Peer Reviewed / Open Access
• [Journal Article] Vitamin D deficiency aggravates diabetes-induced muscle wasting in female mice. (2017)
  • Author(s): Tamura Y, Fujito H, Kawao N, Kaji H
  • Journal Title: Diabetology International Volume: 8 Pages: 52-58
  • NAID: 40021131580
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Role of plasminogen activator inhibitor-1 in glucocorticoid-induced muscle change in mice. (2017)
  • Author(s): Tamura Y, Kawao N, Shimoide T, Okada K, Matsuo O, Kaji H.
  • Journal Title: J Bone Miner Metab Volume: 印刷中 Issue: 2 Pages: 148-156
  • DOI: 10.1007/s00774-017-0825-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The vestibular system is critical for the changes in muscle and bone induced by hypergravity (2016)
  • Author(s): Kawao N, Morita H, Obata K, Tamura Y, Okumoto K and Kaji H
  • Journal Title: Physiological Reports Volume: 4(19) Issue: 19 Pages: 12979-12979
  • DOI: 10.14814/phy2.12979
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Novel roles of FKBP5 in muscle alteration induced by gravity change in mice (2016)
  • Author(s): Shimode T, Kawao N, Tamura Y, Morita H and Kaji H
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 479 Issue: 3 Pages: 602-606
  • DOI: 10.1016/j.bbrc.2016.09.126
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effects of myokines on bone (2016)
  • Author(s): Kaji H
  • Journal Title: IBMS Bonekey Reports Volume: 5 Pages: 826-826
  • DOI: 10.1038/bonekey.2016.48
  • Peer Reviewed
• [Journal Article] Adipose tissue derived PAI-1 function and regulation. (2016)
  • Author(s): Kaji h
  • Journal Title: Comprehensive Physiology Volume: 6 Pages: 1873-1896
  • DOI: 10.1002/cphy.c160004
  • Peer Reviewed
• [Journal Article] Stromal cell-derived factor-1 mediates changes of bone marrow stem cells during the bone repair process. (2016)
  • Author(s): Okada K, Kawao N, Yano M, Tamura Y, Kurashimo S, Okumoto K, Kojima K, Kaji H.
  • Journal Title: Am J Physiol Endocrinol Metab Volume: 1 Issue: 1 Pages: E15-E23
  • DOI: 10.1152/ajpendo.00253.2015
  • Peer Reviewed
• [Presentation] Muscle-derived factor affecting bone metabolism. (2016)
  • Author(s): Kaji H
  • Organizer: The 4th Seoul International Congress of Endocrinology and Metabolism (SICEM 2016)
  • Place of Presentation: Seoul, South Korea
  • Year and Date: 2016-04-29
  • Int'l Joint Research / Invited
• [Presentation] Ｇｒａｖｉｔｙ ｃｈａｎｇｅ ａｎｄ ｍｕｓｃｌｅ／ｂｏｎｅ ｒｅｌａｔｉｏｎｓｈｉｐ (2015)
  • Author(s): 梶博史
  • Organizer: 第１１回国際適応医学会
  • Place of Presentation: 鳥取県米子市米子コンベンションセンター
  • Year and Date: 2015-05-27
  • Int'l Joint Research / Invited