| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
To test the hypothesis that the age-related decline of basal forebrain cholinergic function occurs earlier in the olfactory function, the release of extracellular acetylcholine (ACh), regulation of regional blood flow, and regulation of olfactory processing were measured in the olfactory bulb. The results were compared with the cholinergic function in the neocortex. In aged rats, the extracellular ACh in the olfactory bulb was increased by basal forebrain stimulation, but the amount was smaller than that in the neocortex. Basal forebrain stimulation did not significantly alter the blood flow in the olfactory bulb, while increases were observed in the neocortex. In the olfactory bulb, olfactory stimulation-induced increase in blood flow was potentiated by activation of the alpha4beta2-nicotinic ACh receptors. These results suggest that cholinergic function in the olfactory bulb may be an early marker for cognitive decline.
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