Age related changes in cholinergic function in the olfactory bulb
| Project/Area Number |
15K08225
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
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Principal Investigator |
UCHIDA SAE 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (90270660)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 嗅球 / コリン作動性神経 / 加齢 |
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| Outline of Final Research Achievements |
To test the hypothesis that the age-related decline of basal forebrain cholinergic function occurs earlier in the olfactory function, the release of extracellular acetylcholine (ACh), regulation of regional blood flow, and regulation of olfactory processing were measured in the olfactory bulb. The results were compared with the cholinergic function in the neocortex. In aged rats, the extracellular ACh in the olfactory bulb was increased by basal forebrain stimulation, but the amount was smaller than that in the neocortex. Basal forebrain stimulation did not significantly alter the blood flow in the olfactory bulb, while increases were observed in the neocortex. In the olfactory bulb, olfactory stimulation-induced increase in blood flow was potentiated by activation of the alpha4beta2-nicotinic ACh receptors. These results suggest that cholinergic function in the olfactory bulb may be an early marker for cognitive decline.
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Report
(4 results)
Research Products
(47 results)
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[Presentation] 卵巣機能の自律神経性調節2017
Author(s)
内田さえ
Organizer
第122回日本解剖学会総会・全国学術集会
Place of Presentation
長崎大学坂本キャンパス（長崎県・長崎市）
Year and Date
2017-03-28
Related Report
Invited
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[Presentation] 痛みと自律神経2017
Author(s)
内田さえ
Organizer
千葉県鍼灸師会生涯研修学術講習会
Place of Presentation
千葉市民会館（千葉県・船橋市）
Year and Date
2017-02-12
Related Report
Invited
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[Presentation] The relationship between cerebral blood flow and neuronal activity is altered by systemic blood pressure during nociceptive processing in the primary somatosensory cortex of the rat.2016
Author(s)
Uchida, S., Bois, S., Guillemot, J., Leblond, H., Piche, M.
Organizer
16th World Congress on Pain
Place of Presentation
PACIFICO Yokohama (Yokohama, Kanagawa)
Year and Date
2016-09-26
Related Report
Int'l Joint Research
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