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The role of cell membrane in cytoprotective effects of flavonoids

Research Project

Project/Area Number 15K08228
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General pharmacology
Research InstitutionNagoya University

Principal Investigator

Matsushima Miyoko  名古屋大学, 医学系研究科(保健), 講師 (10509665)

Co-Investigator(Kenkyū-buntansha) 川部 勤  名古屋大学, 医学系研究科(保健), 教授 (20378219)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsフラボノイド / 細胞膜 / heme oxygenase-1 / Nrf2 / caveolin-1 / HO-1
Outline of Final Research Achievements

Flavonoids, which are contained in fruit and vegetables, exhibit wide variety of cytoprotective effects. We previously reported that quercetin exerted various cytoprotective effects via nuclear factor E2-related factor 2 (Nrf2)-heme oxygenase (HO)-1 pathway. In this study, we focused on cell membrane, which is the first line to interact with extracellular environment and plays an important role in cellular signaling, and investigated the involvement of cell membrane changes in quercetin-induced cytoprotective effects. We showed that quercetin changed the formation of lipid rafts by depleting cholesterol from cell membrane. The expression levels of caveolin-1 and Nrf2 localized in cell membrane were also decreased, and caveolin-1-Nrf2 complex was translocated to cytosol and nucleus. These findings suggested that translocation of caveolin-1-Nrf2 complex to nucleus might lead the induction of HO-1.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (35 results)

All 2017 2016 2015

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (30 results) (of which Int'l Joint Research: 9 results)

  • [Journal Article] Heartbeat signal detection from analysis of airflow in rat airway under different depths of anesthesia conditions2017

    • Author(s)
      KAWAOKA Hidenori, YAMADA Takayuki, MATSUSHIMA Miyoko, KAWABE Tsutomu, HASEGAWA Yoshihiro, SHIKIDA Mitsuhiro
    • Journal Title

      IEEE Sensors Journal

      Volume: 17 Issue: 14 Pages: 4369-4377

    • DOI

      10.1109/jsen.2017.2707594

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of basket-forceps-type micro-flow-sensor for breathing measurements in small airway2017

    • Author(s)
      HARADA Naoaki, HASEGAWA Yoshihiro, ONO Ryota, MATSUSHIMA Miyoko, KAWABE Tsutomu, SHIKIDA Mitsuhiro
    • Journal Title

      Microsystem Technologies

      Volume: 23 Issue: 12 Pages: 5397-5406

    • DOI

      10.1007/s00542-016-3265-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Respiration and heartbeat signal detection from airflow at airway in rat by catheter flow sensor with tmeparature compensation function2017

    • Author(s)
      HASEGAWA Yoshihiro, KAWAOKA Hidenori, YAMADA Takayuki, MATSUSHIMA Miyoko, KAWABE Tsutomu, SHIKIDA Mitsuhiro
    • Journal Title

      Journal of Micromechanics and Microengineering

      Volume: 27 Issue: 12 Pages: 1-11

    • DOI

      10.1088/1361-6439/aa9595

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of immunological activity on macrophages induced by diazinon.2017

    • Author(s)
      Ogasawara N, Matsushima M, Kawamura N, Atsumi K, Yamaguchi T, Ochi H, Kusatsugu Y, Oyabu S, Hashimoto N, Hasegawa Y, Ueyama J, Kawabe T.
    • Journal Title

      Toxicology.

      Volume: 379 Pages: 22-30

    • DOI

      10.1016/j.tox.2017.01.014

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The suppressive effect of quercetin on Toll-like receptor 7-mediated activation in alveolar macrophages2015

    • Author(s)
      Yasui M., Matsushima M., Omura A., Mori K., Ogasawara N., Kodera Y., Shiga M., Ito K, Kojima S., Kawabe T.
    • Journal Title

      Pharmacology

      Volume: 96 Issue: 5-6 Pages: 201-209

    • DOI

      10.1159/000438993

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Micromachined tube type thermal flow sensor for adult-sized tracheal intubation tube2017

    • Author(s)
      WATANABE Shun, HASAGAWA Yoshihiro, MATSUSHIMA Miyoko, KAWABE Tsutomu, SHIKIDA Mitsuhiro
    • Organizer
      Eurosensors2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of small-footprint thermal sensor detecting airflow at mouth in baby2017

    • Author(s)
      MITSUNARI Yuuki, HASEGAWA Yoshihiro, MATSUSHIMA Miyoko, KAWABE Tsutomu, SHIKIDA Mitsuhiro
    • Organizer
      Eurosensors2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of catheter flow sensor for breathing measurements at different levels of tracheobronchial airway2017

    • Author(s)
      FUJINORI Tomohiro, HASEGAWA Yoshihiro, MATSUSHIMA Miyoko, KAWABE Tsutomu, SHIKIDA Mitsuhiro
    • Organizer
      Eurosensors2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Integration of flow sensor and optical fiberscope for in-situ breathing and surface image evaluations in small airway2017

    • Author(s)
      OKIHARA Chiaki, HASEGAWA Yoshihiro, MATSUSHIMA Miyoko, KAWABE Tsutomu, SHIKIDA Mitsuhiro
    • Organizer
      19th International Conference on Solid-State Sensors
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis on signal pathway in pro-inflammatory response by diazinon2017

    • Author(s)
      Kazuko Atsumi, Miyoko Matsushima, Kanako Sasou, Tsutomu Kawabe
    • Organizer
      第46回日本免疫学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Deteriorated amount of IC capture without CD40 on B cells2017

    • Author(s)
      Miyoko Matsushima, Kazuko Atsumi, Kanako Sasou, Tsutomu Kawabe
    • Organizer
      第46回日本免疫学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 乳幼児の口元気流計測を目的とした熱式チューブ型マイクロ流量センサの開発2017

    • Author(s)
      光成勇樹、長谷川義大、松島充代子、川部 勤、式田光宏
    • Organizer
      第34回「センサ・マイクロマシンと応用システム」シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 経気管支的に肺機能計測が可能な気管支径対応カテーテル型流量センサの開発2017

    • Author(s)
      藤範知弘、長谷川義大、松島充代子、川部 勤、式田光宏
    • Organizer
      第34回「センサ・マイクロマシンと応用システム」シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 気流検出機能付気管チューブシステムとそれによるその場呼吸計測法に関する研究2017

    • Author(s)
      渡辺 瞬、長谷川義大、松島充代子、川部 勤、式田光宏
    • Organizer
      第34回「センサ・マイクロマシンと応用システム」シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 末梢気道におけるその場観察と呼吸量計測を可能とする光ファイバースコープ搭載型流量センサの開発2017

    • Author(s)
      沖原千明、長谷川 義大、松島充代子、川部 勤、式田 光宏
    • Organizer
      第34回「センサ・マイクロマシンと応用システム」シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] ダイアジノンは骨髄由来マクロファージを活性化させ、免疫応答を修飾する2017

    • Author(s)
      渥美和子、松島充代子、小笠原名奈子、佐宗香奈子、上山 純、川部 勤
    • Organizer
      第48回日本職業・環境アレルギー学会総会・学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 農薬が免疫機能に与える影響についての基礎的検討2017

    • Author(s)
      松島充代子、川部 勤
    • Organizer
      第66回日本アレルギー学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Involvement of localization changes of caveolin-1 in Nrf2 activation induced by quercetin(ケルセチンによるNrf2活性化におけるcaveolin-1の局在変化の関与)2017

    • Author(s)
      Miyoko Matsushima, Yuto Kusatsugu, Haruka Ochi, Sayaka Oyabu, Kazuko Atsumi, Nanako Ogasawara, Tsutomu Kawabe
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎ブリックホール、長崎新聞文化ホール アストピア(長崎県)
    • Related Report
      2016 Research-status Report
  • [Presentation] 呼気エアロゾルを代替血液とした TDM は可能か?2017

    • Author(s)
      谷畑壮磨、山本良平、山本 敦、東海林秀典、加藤祐史、下内章人、松島充代子、川部 勤
    • Organizer
      日本薬学会第137回年会
    • Place of Presentation
      仙台国際センター(宮城県)
    • Related Report
      2016 Research-status Report
  • [Presentation] 分子標的薬のための選択的吸着剤開発2017

    • Author(s)
      大澤磨未、高井里奈、山本良平、山本 敦、松島充代子、川部 勤
    • Organizer
      日本薬学会第137回年会
    • Place of Presentation
      仙台国際センター(宮城県)
    • Related Report
      2016 Research-status Report
  • [Presentation] Involvement of CD40 on Immune Cells in Response to Immune Complexes2016

    • Author(s)
      Kazuko Atsumi, Miyoko Matsushima, Hiroki Ogiso, Haruka Ochi, Yuto Kusatsugu, Sayaka Oyabu, Nanako Ogasawara, Kazuya Takemura, and Tsutomu Kawabe.
    • Organizer
      ICI 2016
    • Place of Presentation
      Melbourne Convention and Exhibition Centre (Australia)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Involvement of CD40 in the Expression of Bcl62016

    • Author(s)
      Haruka Ochi, Miyoko Matsushima, Yuka Kodera, Yuto Kusatsugu, Kazuko Atsumi, Sayaka Oyabu, Nanako Ogasawara, Kazuya Takemura, Tsutomu Kawabe
    • Organizer
      ICI 2016
    • Place of Presentation
      Melbourne Convention and Exhibition Centre (Australia)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Involvement of Caveolin-1 in Quercetin-Induced Nrf2 Activation2016

    • Author(s)
      Miyoko Matsushima, Yuto Kusatsugu, Sayaka Oyabu, Haruka Ochi, Kazuko Atsumi, Nanako Ogasawara, Kazuya Takemura, Tsutomu Kawabe
    • Organizer
      ICI 2016
    • Place of Presentation
      Melbourne Convention and Exhibition Centre (Australia)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Critical Role of Selective Autophagy Adaptor Protein p62 in Quercetin-Induced Nrf2 Activation2016

    • Author(s)
      Yuto Kusatsugu, Miyoko Matsushima, Sayaka Oyabu, Haruka Ochi, Kazuko Atsumi, Nanako Ogasawara, Kazuya Takemura, Tsutomu Kawabe
    • Organizer
      ICI 2016
    • Place of Presentation
      Melbourne Convention and Exhibition Centre (Australia)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Quercetin Suppressed Imiquimod-Induced Activation of Alveolar Macrophages2016

    • Author(s)
      Sayaka Oyabu, Miyoko Matsushima, Aya Omura, Nanako Ogasawara, Haruka Ochi, Yuto Kusatsugu, Kazuko Atsumi, Kazuya Takemura, and Tsutomu Kawabe
    • Organizer
      ICI 2016
    • Place of Presentation
      Melbourne Convention and Exhibition Centre (Australia)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 呼気を使った非侵襲的TDM-呼気エアロゾルの構造2016

    • Author(s)
      谷畑壮磨、山本良平、山本 敦、越智 悠、草次裕人、松島充代子、川部 勤
    • Organizer
      第33回日本TDM学会・学術大会
    • Place of Presentation
      栃木県総合文化センター(栃木県)
    • Related Report
      2016 Research-status Report
  • [Presentation] 症状発現の推測を目論む血清IgEを用いたI型アレルギー検査法の検討2016

    • Author(s)
      松島充代子、川部 勤
    • Organizer
      第65回日本アレルギー学会学術大会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2016 Research-status Report
  • [Presentation] 農薬の環境曝露が免疫機能に及ぼす影響についての基礎的検討2016

    • Author(s)
      渥美和子、松島充代子、小笠原名奈子、武村和也、越智 悠、草次裕人、大薮沙也果、上山 純、川部 勤
    • Organizer
      第47回日本職業・環境アレルギー学会総会・学術大会
    • Place of Presentation
      近畿大学11月ホール(大阪府)
    • Related Report
      2016 Research-status Report
  • [Presentation] 生体防御機構の誘導を指標とした有害物質の評価法の探索2016

    • Author(s)
      大薮沙也果、松島充代子、草次裕人、小笠原名奈子、武村和哉、越智 悠、渥美和子、川部 勤
    • Organizer
      第11回臨床検査学教育学会学術大会
    • Place of Presentation
      神戸常磐大学(兵庫県)
    • Related Report
      2016 Research-status Report
  • [Presentation] The Induction of Macrophage Activation by Diazinon2016

    • Author(s)
      Sayaka Oyabu, Miyoko Matsushima, Kazuko Atsumi, Haruka Ochi, Yuto Kusatsugu, Tsutomu Kawabe
    • Organizer
      第45回日本免疫学会
    • Place of Presentation
      沖縄コンベンションセンター、ラグナガーデンホテル(沖縄県)
    • Related Report
      2016 Research-status Report
  • [Presentation] Somatic hypermutation is not altered without CD40 signaling in T-B interaction2016

    • Author(s)
      Haruka Ochi, Miyoko Matsushima, Yuto Kusatsugu, Kazuko Atsumi, Sayaka Oyabu, Tsutomu Kawabe
    • Organizer
      第45回日本免疫学会
    • Place of Presentation
      沖縄コンベンションセンター、ラグナガーデンホテル(沖縄県)
    • Related Report
      2016 Research-status Report
  • [Presentation] The role of CD40 on immune responses against immune complex2015

    • Author(s)
      Hiroki Ogiso, Miyoko Matsushima, Aya Oomura, Haruka Ochi, Yuto Kusatsugu, Tsutomu Kawabe
    • Organizer
      第44回日本免疫学会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2015-11-20
    • Related Report
      2015 Research-status Report
  • [Presentation] The involvement of autophagy on quercetin-induced Nrf2 activation2015

    • Author(s)
      Yuto Kusatsugu, Miyoko Matsushima, Aya Oomura, Hiroki Ogiso, Haruka Ochi, Tsutomu Kawabe
    • Organizer
      第44回日本免疫学会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2015-11-19
    • Related Report
      2015 Research-status Report
  • [Presentation] 有機リン系殺虫剤による免役応答修飾機構についての検討2015

    • Author(s)
      松島充代子、小笠原名奈子、河村奈美、山口剛広、高木健三、川部 勤
    • Organizer
      第64回日本アレルギー学会学術大会
    • Place of Presentation
      グランドプリンスホテル新高輪国際館パミール
    • Year and Date
      2015-05-26
    • Related Report
      2015 Research-status Report
  • [Presentation] ケルセチンのマウスARDSモデルに対する肺保護作用2015

    • Author(s)
      高嶋浩司、松島充代子、橋本克則、佐藤光夫、橋本直純、長谷川好規、川部 勤
    • Organizer
      第55回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2015-04-17
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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