| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Activation of the m2 muscarinic acetylcholine receptor (m2R) in cardiomyocytes induces the potassium channel opening via the G protein signaling system. This is a molecular mechanism of heart rate control. It has been known that regulators of G protein signaling 4 (RGS4) regulates this intracellular signal transduction system. In this study, we investigated the role in determining the signal transduction efficacies of m2R partial agonists such as pilocarpine. As a result, we found that RGS4 is essential for the characteristics mode of action of m2R partial agonist, such as its voltage dependence, and clarified a part of the structural basis of the underlying mechanism.
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