Regulation of the m2 muscarinic ACh receptor-mediated signaling by RGS proteins
| Project/Area Number |
15K08231
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KURACHI Yoshihisa 大阪大学, 大学院医学系研究科, 教授 (30142011)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 細胞内シグナル伝達 / 受容体 / カリウムチャネル / G蛋白質シグナル / 電気生理学 |
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| Outline of Final Research Achievements |
Activation of the m2 muscarinic acetylcholine receptor (m2R) in cardiomyocytes induces the potassium channel opening via the G protein signaling system. This is a molecular mechanism of heart rate control. It has been known that regulators of G protein signaling 4 (RGS4) regulates this intracellular signal transduction system. In this study, we investigated the role in determining the signal transduction efficacies of m2R partial agonists such as pilocarpine. As a result, we found that RGS4 is essential for the characteristics mode of action of m2R partial agonist, such as its voltage dependence, and clarified a part of the structural basis of the underlying mechanism.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] The Possible Role of TASK Channels in Rank-Ordered Recruitment of Motoneurons in the Dorsolateral Part of the Trigeminal Motor Nucleus.2016
Author(s)
Okamoto K, Emura N, Sato H, Fukatsu Y, Saito M, Tanaka C, Morita Y, Nishimura K, Kuramoto E, Xu Yin D, Furutani K, Okazawa M, Kurachi Y, Kaneko T, Maeda Y, Yamashiro T, Takada K, Toyoda H, Kang Y.
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Journal Title
eNeuro
Volume: 3(3)
Issue: 3
Pages: 3-3
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 心機能障害時のシステム破綻現象2016
Author(s)
古谷和春, 津元国親, 倉智嘉久
Organizer
明治大研究集会「生体と社会のシステム破綻現象」
Place of Presentation
明治大中野キャンパス
Year and Date
2016-06-29
Related Report
Invited
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